Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada.
Prairie Tide Diversified Inc., 102 Melville Street, Saskatoon, SK S7J 0R1, Canada.
Int J Environ Res Public Health. 2021 Apr 4;18(7):3766. doi: 10.3390/ijerph18073766.
The COVID-19 pandemic led to panic-buying of alcohol-based hand rubs (ABHRs). In response, governmental agencies (e.g., Health Canada) permitted the sale of ABHRs formulated with "technical-grade" ethanol to alleviate the growing demand. Technical-grade ethanol contains elevated concentrations of impurities (e.g., acetaldehyde, etc.), which may exhibit dose-dependent toxicity. In this study, a rapid solvent extraction was employed to analyze gelled ABHRs via gas chromatography with flame ionization detection. In total, 26 liquid and 16 gelled ABHRs were analyzed for nine common impurities to determine compliance with Health Canada interim guidelines. Of 42 samples analyzed, 11 ABHRs appear to be non-compliant with interim Health Canada guidelines. Non-compliant ABHRs exhibited elevated concentrations of acetaldehyde, with a maximal concentration observed of 251 ± 10 µL L; 3.3× higher than currently permitted. Nonetheless, frequent testing of ABHRs should be routinely conducted to reduce the risk of consumer exposure to non-compliant ABHRs.
COVID-19 大流行导致了酒精基手部消毒剂（ABHR）的恐慌性购买。为了应对这一情况，政府机构（例如加拿大卫生部）允许销售含有“工业级”乙醇的 ABHR，以缓解日益增长的需求。工业级乙醇含有较高浓度的杂质（例如乙醛等），可能表现出剂量依赖性毒性。在这项研究中，采用快速溶剂萃取法，通过气相色谱法（火焰离子化检测）对凝胶状 ABHR 进行分析。总共分析了 26 种液体和 16 种凝胶状 ABHR，以确定九种常见杂质是否符合加拿大卫生部临时指南。在分析的 42 个样本中，有 11 种 ABHR 似乎不符合加拿大卫生部临时指南的要求。不符合要求的 ABHR 中乙醛浓度升高，最大浓度为 251±10 µL L；比目前允许的浓度高 3.3 倍。尽管如此，仍应定期对 ABHR 进行检测，以降低消费者接触不符合要求的 ABHR 的风险。
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