Abd-Rabboh Hisham S M, E Amr Abd El-Galil, Almehizia Abdulrahman A, Kamel Ayman H
Chemistry Department, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia.
Department of Chemistry, Faculty of Science, Ain Shams University, Cairo 11566, Egypt.
Polymers (Basel). 2021 Apr 7;13(8):1192. doi: 10.3390/polym13081192.
In recent times, the application of the use of ion-selective electrodes has expanded in the field of pharmaceutical analyses due to their distinction from other sensors in their high selectivity and low cost of measurement, in addition to their high measurement sensitivity. Cost-effective, reliable, and robust all-solid-state potentiometric selective electrodes were designed, characterized, and successfully used for pholcodine determination. The design of the sensor device was based on the use of a screen-printed electrode modified with multiwalled carbon nanotubes (MWCNTs) as a solid-contact transducer. Tailored pholcodine (PHO) molecularly imprinted polymers (MIPs) were prepared, characterized, and used as sensory receptors in the presented potentiometric sensing devices. The sensors exhibited a sensitivity of 31.6 ± 0.5 mV/decade ( = 5, = 0.9980) over the linear range of 5.5 × 10 M with a detection limit of 2.5 × 10 M. Real serum samples in addition to pharmaceutical formulations containing PHO were analyzed, and the results were compared with those obtained by the conventional standard liquid chromatographic approach. The presented analytical device showed an outstanding efficiency for fast, direct, and low-cost assessment of pholcodine levels in different matrices.
近年来，离子选择性电极在药物分析领域的应用不断扩展，这是因为与其他传感器相比，它们具有高选择性、低成本测量以及高测量灵敏度的特点。设计、表征并成功使用了具有成本效益、可靠且坚固的全固态电位选择性电极来测定福尔可定。传感器装置的设计基于使用经多壁碳纳米管（MWCNTs）修饰的丝网印刷电极作为固体接触换能器。制备并表征了定制的福尔可定（PHO）分子印迹聚合物（MIPs），并将其用作所展示的电位传感装置中的传感受体。在5.5×10⁻⁶ M至5×10⁻² M的线性范围内，传感器的灵敏度为31.6±0.5 mV/十倍浓度（n = 5，R = 0.9980），检测限为2.5×10⁻⁶ M。除了分析含有PHO的药物制剂外，还对实际血清样本进行了分析，并将结果与通过传统标准液相色谱法获得的结果进行了比较。所展示的分析装置在快速、直接且低成本评估不同基质中福尔可定水平方面表现出卓越的效率。
