Agame-Lagunes Beatriz, Grube-Pagola Peter, García-Varela Rebeca, Alexander-Aguilera Alfonso, García Hugo S
UNIDA, Tecnológico Nacional de México, Instituto Tecnológico de Veracruz, Miguel Ángel de Quevedo 2779, Veracruz, Ver. 91897, Mexico.
Instituto de Investigaciones Medico Biológicas, Universidad Veracruzana, Iturbide s/n, Veracruz, Ver. 91700, Mexico.
Pharmaceutics. 2021 Apr 8;13(4):509. doi: 10.3390/pharmaceutics13040509.
Current changes in diet, characterized by an increase in the intake of sweetened beverages, are heavily related to metabolic disorders such as non-alcoholic fatty liver. This condition can produce simple steatosis and, in worse cases, potentially result in steatohepatitis, fibrosis, and cirrhosis, comparable to the damage caused by the consumption of more or less 20-30 g of alcohol per day. The main objective of this research was to evaluate the effect of curcumin () nanoemulsions, using mono- and diacylglycerides medium chain fatty acids as stabilizers in an in vivo hepatic steatosis rat model. Pathology was induced by providing 30% fructose intake in the drinking water. Globule sizes under 200 nm that were stable for 4 weeks were obtained; curcumin encapsulated in the nanoemulsion was >70%. The results revealed an improvement regarding body and liver weight in the animals treated with curcumin nanoemulsions. A decrease in total cholesterol, LDL, AST/ALT, and HDL in serum was observed; however, no apparent improvement regarding serum glucose or triacylglycerides values was noted. Histological analysis showed a significant decrease in the extent of steatosis, inflammation, and brown adipose tissue in the treated animals.
当前饮食的变化，其特征为含糖饮料摄入量增加，与诸如非酒精性脂肪肝等代谢紊乱密切相关。这种情况可导致单纯性脂肪变性，在更严重的情况下，可能会引发脂肪性肝炎、纤维化和肝硬化，这与每天摄入约20 - 30克酒精所造成的损害相当。本研究的主要目的是在体内肝脂肪变性大鼠模型中，评估以单甘油酯和二甘油酯中链脂肪酸作为稳定剂的姜黄素纳米乳剂的效果。通过在饮用水中提供30%的果糖摄入量来诱发病变。获得了粒径小于200纳米且在4周内稳定的纳米乳剂；包裹在纳米乳剂中的姜黄素含量大于70%。结果显示，用姜黄素纳米乳剂处理的动物在体重和肝脏重量方面有所改善。观察到血清中总胆固醇、低密度脂蛋白、谷草转氨酶/谷丙转氨酶和高密度脂蛋白有所降低；然而，血清葡萄糖或甘油三酯值未见明显改善。组织学分析表明，处理过的动物的脂肪变性、炎症和棕色脂肪组织程度显著降低。
