Sung Ji-Yong, Cheong Jae-Ho
Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul 03722, Korea.
Department of Surgery, Yonsei University College of Medicine, Seoul 03722, Korea.
Cancers (Basel). 2021 Apr 8;13(8):1778. doi: 10.3390/cancers13081778.
Epithelial-mesenchymal transition (EMT) is critical for cancer development, invasion, and metastasis. Its activity influences metabolic reprogramming, tumor aggressiveness, and patient survival. Abnormal tumor metabolism has been identified as a cancer hallmark and is considered a potential therapeutic target. We profiled distinct metabolic signatures by EMT activity using data from 9452 transcriptomes across 31 different cancer types from The Cancer Genome Atlas. Our results demonstrated that ~80 to 90% of cancer types had high carbohydrate and energy metabolism, which were associated with the high EMT group. Notably, among the distinct EMT activities, metabolic reprogramming in different immune microenvironments was correlated with patient prognosis. Nine cancer types showed a significant difference in survival with the presence of high EMT activity. Stomach cancer showed elevated energy metabolism and was associated with an unfavorable prognosis ( < 0.0068) coupled with high expression of , indicating that it may serve as a potential drug target. Our analyses highlight the prevalence of cancer type-dependent EMT and metabolic reprogramming activities and identified metabolism-associated genes that may serve as potential therapeutic targets.
上皮-间质转化（EMT）对癌症的发展、侵袭和转移至关重要。其活性影响代谢重编程、肿瘤侵袭性和患者生存率。异常的肿瘤代谢已被确定为癌症的一个标志，并被认为是一个潜在的治疗靶点。我们利用来自癌症基因组图谱（The Cancer Genome Atlas）的31种不同癌症类型的9452个转录组数据，根据EMT活性分析了不同的代谢特征。我们的结果表明，约80%至90%的癌症类型具有高碳水化合物和能量代谢，这与高EMT组相关。值得注意的是，在不同的EMT活性中，不同免疫微环境中的代谢重编程与患者预后相关。九种癌症类型在高EMT活性存在时生存率有显著差异。胃癌表现出能量代谢升高，与不良预后（<0.0068）相关，且 高表达，表明它可能作为一个潜在的药物靶点。我们的分析突出了癌症类型依赖性EMT和代谢重编程活动的普遍性，并确定了可能作为潜在治疗靶点的代谢相关基因。
