Seban Romain-David, Champion Laurence, Deleval Nicolas, Richard Capucine, Provost Claire
Department of Nuclear Medicine and Endocrine Oncology, Institut Curie, 92210 Saint-Cloud, France.
Laboratoire d'Imagerie Translationnelle en Oncologie, Inserm, Institut Curie, 91401 Orsay, France.
Diagnostics (Basel). 2021 Apr 9;11(4):676. doi: 10.3390/diagnostics11040676.
Worldwide deployment of COVID-19 vaccines is in progress. Recent immune activation following vaccination can sometimes be seen in fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ([18F]-FDG PET/CT). As previously evidenced, FDG-avid axillary lymph node(s) are common in patients receiving vaccines against SARS-CoV-2, influenza virus, or human papillomavirus, and reflect a regional immune response. In addition, these findings may also be accompanied by an increased spleen glucose metabolism after the COVID-19 vaccine, which captures a systemic immune response. Hence, we provide here a clinical example demonstrating that immune response could be associated with increased glucose metabolism in lymphoid organs such as lymph nodes and the spleen, which are critical modulators of T cell immunity. We believe that it is of paramount importance that nuclear physicians should be able to recognize clinical and imaging features of such immune responses upon vaccination for COVID-19 and beyond.
全球范围内正在进行新型冠状病毒肺炎（COVID-19）疫苗的接种。接种疫苗后近期出现的免疫激活有时可在氟-18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（[18F]-FDG PET/CT）中观察到。如先前所示，接受严重急性呼吸综合征冠状病毒2（SARS-CoV-2）、流感病毒或人乳头瘤病毒疫苗接种的患者中，FDG摄取阳性的腋窝淋巴结很常见，反映了局部免疫反应。此外，这些发现可能还伴有COVID-19疫苗接种后脾脏葡萄糖代谢增加，这体现了全身免疫反应。因此，我们在此提供一个临床实例，证明免疫反应可能与淋巴结和脾脏等淋巴器官中葡萄糖代谢增加有关，而这些器官是T细胞免疫的关键调节因子。我们认为，核医学医师能够识别COVID-19及其他疫苗接种后此类免疫反应的临床和影像特征至关重要。
