SEGES Danish Pig Research Centre, Agro Food Park 15V, DK-8200 Aarhus N, Denmark.
Department of Virus & Microbiological Special Diagnostics, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark.
Viruses. 2021 Apr 21;13(5):717. doi: 10.3390/v13050717.
Atypical porcine pestivirus (APPV) was first discovered in North America in 2015 and was later shown to be associated with congenital tremor (CT) in piglets. CT is an occasional challenge in some Danish sow herds. Therefore, we initiated an observational case control study to clarify a possible relationship between CT and APPV in Danish pig production. Blood samples were collected from piglets affected by CT ( = 55) in ten different sow herds and from healthy piglets in five sow herds without a history of CT piglets ( = 25), as well as one sow herd with a sporadic occurrence of CT ( = 5). APPV was detected by RT-qPCR in all samples from piglets affected by CT and in three out of five samples from piglets in the herd with a sporadic occurrence of CT. In the herds without a history of CT, only one out of 25 piglets were positive for APPV. In addition, farmers or veterinarians in CT-affected herds were asked about their experience of the issue. CT is most often seen in gilt litters, and a substantial increase in pre-weaning mortality is only observed in severe cases. According to our investigations, APPV is a common finding in piglets suffering from CT in Denmark.
非典型猪瘟病毒（APPV）于 2015 年首次在北美被发现，后来被证明与仔猪先天性震颤（CT）有关。CT 是丹麦一些母猪群中偶尔出现的问题。因此，我们开展了一项观察性病例对照研究，以阐明 APPV 在丹麦养猪生产中与 CT 之间的可能关系。从在十个不同母猪群中患有 CT 的仔猪（=55 头）和五个没有 CT 仔猪历史的母猪群中健康仔猪（=25 头）以及一个 CT 偶发母猪群中（=5 头）采集仔猪血液样本。在所有患有 CT 的仔猪样本以及在 CT 偶发母猪群中 5 个样本中的 3 个样本中，均通过 RT-qPCR 检测到 APPV。在没有 CT 历史的母猪群中，25 头仔猪中只有 1 头呈 APPV 阳性。此外，还询问了 CT 感染猪群的饲养员或兽医有关该问题的经验。CT 最常发生在后备母猪产仔中，仅在严重情况下才会观察到断奶前死亡率的显著增加。根据我们的调查，APPV 是丹麦患有 CT 的仔猪的常见发现。
