Round Andrew M, Joo Min Cheol, Barakso Carolyn M, Fallah Nader, Noonan Vanessa K, Krassioukov Andrei V
International Collaboration on Repair Discoveries (ICORD), Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
J Clin Med. 2021 Apr 14;10(8):1673. doi: 10.3390/jcm10081673.
To explore the association between bowel dysfunction and use of laxatives and opioids in an acute rehabilitation setting following spinal cord injury (SCI).
Data was collected regarding individuals with acute traumatic/non-traumatic SCI over a two-year period (2012-2013) during both the week of admission and discharge of their inpatient stay.
An increase in frequency of bowel movement (BM) ( = 0.003) and a decrease in frequency of fecal incontinence (FI) per week ( < 0.001) between admission and discharge was found across all participants. There was a reduction in the number of individuals using laxatives ( = 0.004) as well as the number of unique laxatives taken ( < 0.001) between admission and discharge in our cohort. The number of individuals using opioids and the average dose of opioids in morphine milligram equivalents (MME) from admission to discharge were significantly reduced ( = 0.001 and = 0.02, respectively). There was a positive correlation between the number of laxatives and frequency of FI at discharge (r = 0.194, = 0.014), suggesting that an increase in laxative use results in an increased frequency of FI. Finally, there was a significant negative correlation between average dose of opioids (MME) and frequency of BM at discharge, confirming the constipating effect of opioids (r = -0.20, = 0.009).
探讨脊髓损伤（SCI）后急性康复环境中肠道功能障碍与泻药和阿片类药物使用之间的关联。
收集了2012年至2013年两年期间急性创伤性/非创伤性SCI患者在住院期间入院和出院当周的数据。
在所有参与者中，发现入院和出院之间每周排便次数（BM）增加（P = 0.003），粪便失禁（FI）频率降低（P < 0.001）。在我们的队列中，入院和出院之间使用泻药的人数（P = 0.004）以及服用的独特泻药数量（P < 0.001）均有所减少。从入院到出院，使用阿片类药物的人数和以吗啡毫克当量（MME）计的阿片类药物平均剂量均显著降低（分别为P = 0.001和P = 0.02）。出院时泻药数量与FI频率之间存在正相关（r = 0.194，P = 0.014），表明泻药使用增加会导致FI频率增加。最后，出院时阿片类药物平均剂量（MME）与BM频率之间存在显著负相关，证实了阿片类药物的便秘作用（r = -0.20，P = 0.009）。
