Xu Chenkai, Song Yongfu, Lan Yuejiao, Wang Yongji, Wang Na, Lu Xiaodan
College of Integrative Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, China.
Precision Medicine Center, Jilin Province General Hospital, Changchun, Jilin, China.
Front Cardiovasc Med. 2024 Oct 17;11:1447913. doi: 10.3389/fcvm.2024.1447913. eCollection 2024.
There is limited amount of research on the association between fecal incontinence (FI) and cardiovascular disease (CVD). This study aims to evaluate whether there is a relationship between FI and CVD among adults in the United States.
This study employed a cross-sectional design, encompassing 11,237 adults aged 20 years and older, drawn from the National Health and Nutrition Survey conducted from 2005 to 2010. FI was defined as the involuntary monthly leakage of solid, liquid, or mucus stool. The presence of CVD was evaluated through a questionnaire. Adjusted odds ratios (OR) were computed utilizing a multivariate logistic regression model. Subgroup analyses were conducted to ascertain the stability of the results.
Following adjustments for population characteristics, lifestyle habits, laboratory tests, and comorbidities, a significant association was observed between FI and elevated CVD risk (OR: 1.47, 95% CI: 1.21-1.79, < 0.001). Subgroup analysis uncovered a strong correlation between FI and CVD among participants aged 45-65 years (OR: 1.78, 95%CI: 1.31-2.43). In the participants to aged 66 and above, this correlation persisted (OR: 1.31, 95% CI: 1.01-1.70).
This study reveals a significant positive correlation between FI and CVD. Middle-aged and older adults are considered high-risk population for developing CVD, thus emphasizing the importance of screening and timely intervention.
关于大便失禁（FI）与心血管疾病（CVD）之间关联的研究数量有限。本研究旨在评估美国成年人中FI与CVD之间是否存在关联。
本研究采用横断面设计，纳入了2005年至2010年进行的美国国家健康与营养调查中的11237名20岁及以上的成年人。FI被定义为每月非自愿地漏出固体、液体或黏液粪便。通过问卷调查评估CVD的存在情况。利用多变量逻辑回归模型计算调整后的比值比（OR）。进行亚组分析以确定结果的稳定性。
在对人口特征、生活方式习惯、实验室检查和合并症进行调整后，观察到FI与CVD风险升高之间存在显著关联（OR：1.47，95%CI：1.21 - 1.79，P < 0.001）。亚组分析发现45 - 65岁参与者中FI与CVD之间存在强相关性（OR：1.78，95%CI：1.31 - 2.43）。在66岁及以上的参与者中，这种相关性仍然存在（OR：1.31，95%CI：1.01 - 1.70）。
本研究揭示了FI与CVD之间存在显著的正相关。中年及老年人被认为是发生CVD的高危人群，因此强调了筛查和及时干预的重要性。
