Clinical Cytomics Facility, University Institute of Clinical Chemistry, University Hospital Bern, Inselspital, CH-3010 Bern, Switzerland.
Institute of Social and Preventive Medicine, University Bern, CH-3012 Bern, Switzerland.
Cells. 2021 Apr 14;10(4):895. doi: 10.3390/cells10040895.
Eosinophils are well known to contribute significantly to Th2 immunity, such as allergic inflammations. Although basophils have often not been considered in the pathogenicity of allergic dermatitis and asthma, their role in Th2 immunity has become apparent in recent years. Eosinophils and basophils are present at sites of allergic inflammations. It is therefore reasonable to speculate that these two types of granulocytes interact in vivo. In various experimental allergy models, basophils and eosinophils appear to be closely linked by directly or indirectly influencing each other since they are responsive to similar cytokines and chemokines. Indeed, basophils are shown to be the gatekeepers that are capable of regulating eosinophil entry into inflammatory tissue sites through activation-induced interactions with endothelium. However, the direct evidence that eosinophils and basophils interact is still rarely described. Nevertheless, new findings on the regulation and function of eosinophils and basophils biology reported in the last 25 years have shed some light on their potential interaction. This review will focus on the current knowledge that basophils may regulate the biology of eosinophil in atopic dermatitis and allergic asthma.
嗜酸性粒细胞众所周知在 Th2 免疫中发挥重要作用，例如过敏炎症。虽然嗜碱性粒细胞在过敏性皮炎和哮喘的发病机制中常常不被考虑，但近年来它们在 Th2 免疫中的作用已变得明显。嗜酸性粒细胞和嗜碱性粒细胞存在于过敏炎症部位。因此，可以合理地推测这两种类型的粒细胞在体内相互作用。在各种实验性过敏模型中，嗜碱性粒细胞和嗜酸性粒细胞似乎通过直接或间接相互影响密切相关，因为它们对相似的细胞因子和趋化因子有反应。事实上，嗜碱性粒细胞被证明是能够通过与内皮细胞的激活诱导相互作用来调节嗜酸性粒细胞进入炎症组织部位的守门员。然而，嗜酸性粒细胞和嗜碱性粒细胞相互作用的直接证据仍然很少描述。尽管如此，过去 25 年报道的关于嗜酸性粒细胞和嗜碱性粒细胞生物学的调节和功能的新发现，为它们的潜在相互作用提供了一些线索。本文综述了嗜碱性粒细胞可能调节特应性皮炎和过敏性哮喘中嗜酸性粒细胞生物学的最新知识。
