Ștefănescu Ruxandra, Farczadi Lenard, Huțanu Adina, Ősz Bianca E, Mărușteri Marius, Negroiu Ancuța, Vari Camil E
Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
Plants (Basel). 2021 Apr 10;10(4):744. doi: 10.3390/plants10040744.
The present project aims to evaluate (TT) extracts by addressing various possible mechanisms of action in order to see whether the use of TT supplements in diabetes and diabetes complications is justified. Diabetic rats were divided into three groups: diabetic control group, TT extract with low protodioscin content group (TT-LPC) and TT extract with high protodioscin content group (TT-HPC). After twelve weeks of treatment, fasting blood glucose, insulin, LH, FSH and testosterone levels were measured. Both TT preparations reduced elevated blood glucose level. Insulin and luteinizing hormone levels were not significantly different compared with the control group; however, the FSH and testosterone levels were significantly higher in the TT-HPC group compared with the diabetic control group. The testosterone level is correlated in part with the protodioscin concentration in extracts and is probably mediated through an FSH-linked pathway.
本项目旨在通过探讨各种可能的作用机制来评估（TT）提取物，以确定在糖尿病及其并发症中使用TT补充剂是否合理。将糖尿病大鼠分为三组：糖尿病对照组、原薯蓣皂苷含量低的TT提取物组（TT-LPC）和原薯蓣皂苷含量高的TT提取物组（TT-HPC）。治疗十二周后，测量空腹血糖、胰岛素、促黄体生成素（LH）、促卵泡生成素（FSH）和睾酮水平。两种TT制剂均降低了升高的血糖水平。与对照组相比，胰岛素和促黄体生成素水平无显著差异；然而，与糖尿病对照组相比，TT-HPC组的促卵泡生成素和睾酮水平显著更高。睾酮水平部分与提取物中原薯蓣皂苷浓度相关，可能通过FSH相关途径介导。
