Kasuga N C, Sekino K, Koumo C, Shimada N, Ishikawa M, Nomiya K
Department of Materials Science, Faculty of Science, Kanagawa University, Hiratsuka, Japan.
J Inorg Biochem. 2001 Mar;84(1-2):55-65. doi: 10.1016/s0162-0134(00)00221-x.
To investigate the relationship between antimicrobial activities and the molecular structures of nickel(II) complexes with thiosemicarbazone and semicarbazone ligands, nickel(II) complexes with ligands Hmtsc, Hatsc, Hasc and H2dmtsc, were prepared and characterized by elemental analysis, FT-IR, 1H and 13C NMR spectroscopies, magnetic susceptibility measurements, UV-Vis absorption spectra, TG/DTA and single-crystal X-ray analysis. Their antimicrobial activities were evaluated by the MIC against four bacteria (B. subtilis, S. aureus, E. coli and P. aeruginosa), two yeasts (C. albicans and S. cerevisiae) and two molds (A. niger and P. citrinum). The 4-coordinate, diamagnetic nickel(II) complexes showed antimicrobial activities which were different from those of free ligands or the starting nickel(II) compounds; [Ni(mtsc)(OAc)] 1 showed selective and effective antimicrobial activities against two Gram-positive bacteria (B. subtilis and S. aureus) and modest activities against a yeast (S. cerevisiae), [Ni(mtsc)Cl] 3 exhibited moderate activities against a Gram-positive bacterium (S. aureus), and [Ni(atsc)(OAc)] 5 showed modest activities against two Gram-positive bacteria (B. subtilis and S. aureus). On the other hand, the 6-coordinate, paramagnetic nickel(II) complexes with two protonated or deprotonated ligands ([Ni(mtsc)2] 2, [Ni(atsc)(mtsc)] 4, [Ni(atsc)2] 6, Ni(Hatsc)2(2)7, [Ni(Hatsc)2]Cl(2)8 and Ni(Hasc)2(2)9) and the sterically crowded 4-coordinate, diamagnetic nickel(II) complex ([Ni(dmtsc)] 10) did not inhibit the growth of the test organisms. The structure-activity correlation in this series of nickel(II) complexes was discussed based on their ligand-replacement abilities.
为了研究镍（II）与硫代氨基脲和氨基脲配体配合物的抗菌活性与分子结构之间的关系，制备了镍（II）与配体Hmtsc、Hatsc、Hasc和H2dmtsc的配合物，并通过元素分析、傅里叶变换红外光谱（FT-IR）、1H和13C核磁共振光谱、磁化率测量、紫外可见吸收光谱、热重/差示热分析（TG/DTA）以及单晶X射线分析对其进行了表征。通过对四种细菌（枯草芽孢杆菌、金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌）、两种酵母（白色念珠菌和酿酒酵母）以及两种霉菌（黑曲霉和桔青霉）的最低抑菌浓度（MIC）评估了它们的抗菌活性。四配位的抗磁性镍（II）配合物表现出与游离配体或起始镍（II）化合物不同的抗菌活性；[Ni(mtsc)(OAc)] 1对两种革兰氏阳性细菌（枯草芽孢杆菌和金黄色葡萄球菌）表现出选择性和有效的抗菌活性，对一种酵母（酿酒酵母）表现出适度的活性，[Ni(mtsc)Cl] 3对一种革兰氏阳性细菌（金黄色葡萄球菌）表现出中等活性，[Ni(atsc)(OAc)] 5对两种革兰氏阳性细菌（枯草芽孢杆菌和金黄色葡萄球菌）表现出适度活性。另一方面，具有两个质子化或去质子化配体的六配位顺磁性镍（II）配合物（[Ni(mtsc)2] 2、[Ni(atsc)(mtsc)] 4、[Ni(atsc)2] 6、Ni(Hatsc)2(2)7、[Ni(Hatsc)2]Cl(2)8和Ni(Hasc)2(2)9）以及空间位阻较大的四配位抗磁性镍（II）配合物（[Ni(dmtsc)] 10）没有抑制受试生物的生长。基于它们的配体取代能力，讨论了这一系列镍（II）配合物的构效关系。
