Marzo Florencio, Milagro Fermin I, Barrenetxe Jaione, Díaz María Teresa, Martínez J Alfredo
Laboratory of Animal Physiology and Nutrition, School of Agronomy, Universidad Pública de Navarra, 31006 Pamplona, Spain.
ISFOOD (Research Institute for Innovation & Sustainable Development in Food Chain), Universidad Pública de Navarra, 31006 Pamplona, Spain.
Foods. 2021 Apr 15;10(4):863. doi: 10.3390/foods10040863.
Obesity is considered a risk factor for the development of colorectal cancer. In rodents, high-fat (HF) diets are able to increase the formation of azoxymethane (AOM)-induced polyps. Polyphenol-rich apple extracts have antioxidant and anti-inflammatory activities and may induce an amelioration of the manifestations of colorectal cancer. Twenty-seven male Crl:CD-1 mice received AOM during four weeks and were subsequently divided into three groups fed a HF diet ( = 9 each group): a non-supplemented group, a second group supplemented with apple extract at 1%, and a third group supplemented with the same apple extract at 1.5%. Energy metabolism and the respiratory quotient were not affected by the supplementation with the apple extract. Although body weight was not affected by the treatment, the mice supplemented with the apple extract showed less signs of cachexia than the non-treated mice. In the intestine, the mice supplemented with the apple extract showed lower sucrase, dipeptidyl-peptidase IV, and aminopeptidase N activities, and less intestinal lesions (aberrant crypt foci and polyps). Administration of a polyphenol-rich apple extract reduces the number of neoplastic lesions in mice with AOM-induced colorectal cancer and contributes to preserve adipose tissue mass.
肥胖被认为是结直肠癌发生的一个风险因素。在啮齿动物中，高脂（HF）饮食能够增加由氧化偶氮甲烷（AOM）诱导的息肉形成。富含多酚的苹果提取物具有抗氧化和抗炎活性，可能会改善结直肠癌的表现。27只雄性Crl:CD-1小鼠在四周内接受了AOM处理，随后被分为三组，每组9只，喂食高脂饮食：一组不补充，第二组补充1%的苹果提取物，第三组补充1.5%的相同苹果提取物。能量代谢和呼吸商不受苹果提取物补充的影响。虽然体重不受治疗影响，但补充苹果提取物的小鼠比未治疗的小鼠表现出更少的恶病质迹象。在肠道中，补充苹果提取物的小鼠蔗糖酶、二肽基肽酶IV和氨肽酶N的活性较低，肠道病变（异常隐窝灶和息肉）也较少。给予富含多酚的苹果提取物可减少AOM诱导的结直肠癌小鼠的肿瘤性病变数量，并有助于维持脂肪组织量。
