Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto 860-0082, Japan.
DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-Ku, Kumamoto 860-0082, Japan.
Int J Mol Sci. 2024 Mar 1;25(5):2849. doi: 10.3390/ijms25052849.
Aflatoxins are harmful natural contaminants found in foods and are known to be hepatotoxic. However, recent studies have linked chronic consumption of aflatoxins to nephrotoxicity in both animals and humans. Here, we conducted a systematic review of active compounds, crude extracts, herbal formulations, and probiotics against aflatoxin-induced renal dysfunction, highlighting their mechanisms of action in both in vitro and in vivo studies. The natural products and dietary supplements discussed in this study alleviated aflatoxin-induced renal oxidative stress, inflammation, tissue damage, and markers of renal function, mostly in animal models. Therefore, the information provided in this review may improve the management of kidney disease associated with aflatoxin exposure and potentially aid in animal feed supplementation. However, future research is warranted to translate the outcomes of this study into clinical use in kidney patients.
黄曲霉毒素是存在于食物中的有害天然污染物，已知具有肝毒性。然而，最近的研究将慢性摄入黄曲霉毒素与动物和人类的肾毒性联系起来。在这里，我们对针对黄曲霉毒素诱导的肾功能障碍的活性化合物、粗提取物、草药配方和益生菌进行了系统综述，强调了它们在体外和体内研究中的作用机制。本研究讨论的天然产品和膳食补充剂减轻了黄曲霉毒素诱导的肾氧化应激、炎症、组织损伤和肾功能标志物，主要在动物模型中。因此，本综述提供的信息可能有助于改善与黄曲霉毒素暴露相关的肾脏疾病的管理，并可能有助于动物饲料的补充。然而，需要进一步的研究将本研究的结果转化为肾病患者的临床应用。
