Silva Cassio Nazareno Silva da, Di-Medeiros Maria Carolina Bezerra, Lião Luciano Morais, Fernandes Kátia Flávia, Batista Karla de Aleluia
Laboratório de Química de Polímeros, Instituto de Ciências Biológicas, ICB2, Campus Samambaia, Universidade Federal de Goiás, Goiânia 74690-900, GO, Brazil.
Laboratório de Ressonância Nuclear Magnética, Universidade Federal de São Carlos, São Carlos 13565-905, SP, Brazil.
Materials (Basel). 2021 Apr 22;14(9):2115. doi: 10.3390/ma14092115.
This investigation focuses on the development and optimization of cashew gum polysaccharide (CGP) nanoparticles grafted with polypropylene glycol (PPG) as carriers for diclofenac sodium. The optimization of parameters affecting nanoparticles formulation was performed using a central composite rotatable design (CCRD). It was demonstrated that the best formulation was achieved when 10 mg of CGP was mixed with 10 μL of PPG and homogenized at 22,000 rpm for 15 min. The physicochemical characterization evidenced that diclofenac was efficiently entrapped, as increases in the thermal stability of the drug were observed. The CGP-PPG@diclofenac nanoparticles showed a globular shape, with smooth surfaces, a hydrodynamic diameter around 275 nm, a polydispersity index (PDI) of 0.342, and a zeta potential of -5.98 mV. The kinetic studies evidenced that diclofenac release followed an anomalous transport mechanism, with a sustained release up to 68 h. These results indicated that CGP-PPG nanoparticles are an effective material for the loading/release of drugs with similar structures to diclofenac sodium.
本研究聚焦于接枝聚丙二醇（PPG）的腰果胶多糖（CGP）纳米颗粒的开发与优化，以作为双氯芬酸钠的载体。采用中心复合旋转设计（CCRD）对影响纳米颗粒制剂的参数进行优化。结果表明，当10 mg CGP与10 μL PPG混合并在22,000 rpm下均质15分钟时，可获得最佳制剂。物理化学表征证明双氯芬酸被有效包封，因为观察到药物的热稳定性有所提高。CGP-PPG@双氯芬酸纳米颗粒呈球形，表面光滑，流体动力学直径约为275 nm，多分散指数（PDI）为0.342，zeta电位为-5.98 mV。动力学研究证明双氯芬酸的释放遵循非正规转运机制，可持续释放长达68小时。这些结果表明，CGP-PPG纳米颗粒是一种用于负载/释放与双氯芬酸钠结构相似药物的有效材料。
