Department of Nephrology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany.
Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany.
Int J Environ Res Public Health. 2021 Apr 25;18(9):4540. doi: 10.3390/ijerph18094540.
SARS-CoV-2 is a worldwide challenge for the medical sector. Healthcare workers (HCW) are a cohort vulnerable to SARS-CoV-2 infection due to frequent and close contact with COVID-19 patients. However, they are also well trained and equipped with protective gear. The SARS-CoV-2 IgG antibody status was assessed at three different time points in 450 HCW of the University Hospital Essen in Germany. HCW were stratified according to contact frequencies with COVID-19 patients in (I) a high-risk group with daily contacts with known COVID-19 patients (n = 338), (II) an intermediate-risk group with daily contacts with non-COVID-19 patients (n = 78), and (III) a low-risk group without patient contacts (n = 34). The overall seroprevalence increased from 2.2% in March-May to 4.0% in June-July to 5.1% in October-December. The SARS-CoV-2 IgG detection rate was not significantly different between the high-risk group (1.8%; 3.8%; 5.5%), the intermediate-risk group (5.1%; 6.3%; 6.1%), and the low-risk group (0%, 0%, 0%). The overall SARS-CoV-2 seroprevalence remained low in HCW in western Germany one year after the outbreak of COVID-19 in Germany, and hygiene standards seemed to be effective in preventing patient-to-staff virus transmission.
SARS-CoV-2 对医疗行业来说是一个全球性的挑战。医护人员（HCW）由于经常与 COVID-19 患者密切接触，因此是易感染 SARS-CoV-2 的人群。但是，他们也经过了良好的培训并配备了防护装备。在德国埃森大学医院，对 450 名 HCW 的 SARS-CoV-2 IgG 抗体状况进行了三次不同时间点的评估。根据与 COVID-19 患者接触的频率，将 HCW 分为（I）高风险组，每天与已知 COVID-19 患者接触（n = 338），（II）中风险组，每天与非 COVID-19 患者接触（n = 78），以及（III）低风险组，无患者接触（n = 34）。总体血清阳性率从 3 月至 5 月的 2.2%上升到 6 月至 7 月的 4.0%，再上升到 10 月至 12 月的 5.1%。高风险组（1.8%；3.8%；5.5%）、中风险组（5.1%；6.3%；6.1%）和低风险组（0%；0%；0%）之间的 SARS-CoV-2 IgG 检出率没有显著差异。一年后德国 COVID-19 爆发，在德国西部的 HCW 中，SARS-CoV-2 的总体血清阳性率仍然较低，卫生标准似乎有效地防止了患者向工作人员传播病毒。
