[重症监护病房及临床医护人员体内的新型冠状病毒抗体：来自德国感染率最高地区的情况]

[SARS-CoV-2 antibodies in ICU and clinic staff : From Germany's region with the highest infection rate].

作者信息

Finkenzeller T, Faltlhauser A, Dietl K-H, Paetzel C, Szczypien N, Klawonn F, Bodmann K-F, von Meyer A

机构信息

Institut für Radiologische Diagnostik, interventionelle Radiologie und Neuroradiologie, Kliniken Nordoberpfalz AG, Söllnerstraße 16, 92637, Weiden i. d. OPf., Deutschland.

Medizinische Klinik I, Kliniken Nordoberpfalz AG, Weiden i. d. OPf., Deutschland.

出版信息

Med Klin Intensivmed Notfmed. 2020 Dec;115(Suppl 3):139-145. doi: 10.1007/s00063-020-00761-5. Epub 2020 Dec 3.

DOI:10.1007/s00063-020-00761-5

PMID:33274410

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7713905/

Abstract

BACKGROUND

Healthcare workers are a high-risk population for SARS-CoV‑2 infection. For capacity planning of healthcare providers and to optimize protection of healthcare workers (HCW) in SARS-CoV‑2 pandemics, it is essential to know the risk of infection and potential immunity status of staff dealing with COVID-19 patients.

MATERIALS AND METHODS

We examined seropravalence of SARS-CoV‑2 IgM/IgG antibodies (AB) in HCW of a region with the highest rate of infection (1570/100,000) during COVID-19 pandemic in Germany, 4 months after its start. Employees of a nonmedical company (MU) served as control group. Demographic data, medical history and working situation were recorded.

RESULTS

A total of 1838 HCW and 986 MU volunteered to participate. Seroprevalence for SARS-CoV‑2 in HCW was 15.1% and 3.7% in MU. Among HCWs, nurses had a seropositivity of 20.0%, ICU personnel 20.3%, housekeepers 19.3%, physicians 12.0%, medical services (e.g., radiology, physiotherapy) 11.3%, administration 7.1% and technical services 6%. Symptoms typical for COVID-19 were not experienced by 10% of seropositive HCWs.

CONCLUSION

Seroprevalence of SARS-CoV‑2 antibodies in HCW of a region heavily affected by COVID-19 is with 15.1% significantly higher than in a control group of nonmedical staff with 3.7%. Infection rate in HCW was higher in staff with close contact to infected patients. Seropositivity in ICU personnel is higher than in other clinical professions. The occupational risk for housekeepers seems to be underestimated.

摘要

背景

医护人员是感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的高危人群。为了进行医疗服务提供者的能力规划，并在SARS-CoV-2大流行期间优化对医护人员的保护，了解接触2019冠状病毒病（COVID-19）患者的工作人员的感染风险和潜在免疫状态至关重要。

材料与方法

我们检测了德国COVID-19大流行开始4个月后感染率最高（1570/10万）地区医护人员中SARS-CoV-2 IgM/IgG抗体（AB）的血清阳性率。一家非医疗公司（MU）的员工作为对照组。记录人口统计学数据、病史和工作情况。

结果

共有1838名医护人员和986名MU员工自愿参与。医护人员中SARS-CoV-2的血清阳性率为15.1%，MU员工中为3.7%。在医护人员中，护士的血清阳性率为20.0%，重症监护室人员为20.3%，勤杂人员为19.3%，医生为12.0%，医疗服务人员（如放射科、理疗科）为11.3%，行政人员为7.1%，技术服务人员为6%。10%的血清阳性医护人员未出现COVID-19的典型症状。