微小 RNA 在颅面骨形成、再生和修复中的功能。
MicroRNA function in craniofacial bone formation, regeneration and repair.
机构信息
Iowa Institute for Oral Health Research, The University of Iowa, Iowa City, IA, USA.
Iowa Institute for Oral Health Research, The University of Iowa, Iowa City, IA, USA; The University of Iowa, Department of Anatomy and Cell Biology, Iowa City, IA, USA; Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, IA, USA.
出版信息
Bone. 2021 Mar;144:115789. doi: 10.1016/j.bone.2020.115789. Epub 2020 Dec 9.
Abstract
Bone formation in the craniofacial complex is regulated by cranial neural crest (CNC) and mesoderm-derived cells. Different elements of the developing skull, face, mandible, maxilla (jaws) and nasal bones are regulated by an array of transcription factors, signaling molecules and microRNAs (miRs). miRs are molecular modulators of these factors and act to restrict their expression in a temporal-spatial mechanism. miRs control the different genetic pathways that form the craniofacial complex. By understanding how miRs function in vivo during development they can be adapted to regenerate and repair craniofacial genetic anomalies as well as bone diseases and defects due to traumatic injuries. This review will highlight some of the new miR technologies and functions that form new bone or inhibit bone regeneration.
摘要
颅面复合体中的骨形成受颅神经嵴（CNC）和中胚层衍生细胞的调节。发育中的颅骨、面部、下颌骨、上颌骨（颌骨）和鼻骨的不同元素受一系列转录因子、信号分子和 microRNAs（miRs）的调节。miRs 是这些因子的分子调节剂，作用是在时空机制中限制它们的表达。miRs 控制形成颅面复合体的不同遗传途径。通过了解它们在发育过程中体内的功能，它们可以被调整以再生和修复颅面遗传异常以及由于创伤性损伤导致的骨疾病和缺陷。这篇综述将重点介绍一些新的 miR 技术和功能，这些技术和功能可以形成新的骨骼或抑制骨骼再生。
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