Jang Min-Ho, Park Young-Bum, Kwon Jae-Sung, Kim Yeun-Ju, Lee Jae-Hoon
Department of Prosthodontics, Yonsei University College of Dentistry, Seoul 03722, Korea.
Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul 03722, Korea.
Materials (Basel). 2021 Apr 13;14(8):1942. doi: 10.3390/ma14081942.
Osseointegration of titanium implant is important for the success of both dental and medical implants. Previous studies have attempted to improve osseointegration by considering the use of plasma jet technology, where information with animal models and parameters related to osseointegration is still lacking. Therefore, this study investigated the effects of non-thermal atmospheric pressure plasma jet (NTAPPJ) treatment on titanium implants in terms of osseointegration in mongrel dogs. A total of 41 implants; 21 NTAPPJ treated and 20 control, were placed in the maxilla and mandible of six mongrel dogs for either 4 or 8 weeks. The bone volume (BV) and bone-to-implant contact (BIC) ratio were determined by region of interest (ROI). Statistical analysis was performed with the Wilcoxon rank-sum test. The NTAPPJ group at 4 weeks showed higher numbers in both BV and BIC ( < 0.05) compared to the control group. However, at 8 weeks there were less significant differences between the control or experimental group as the control group had caught up with the experimental group. Hence, NTAPPJ may be an effective treatment for the initial healing period which is critical to ensure reliable long-term predictability. The BV and BIC have been clinically proven to accelerate in the initial stages with the use of NTAPPJ to aid in the healing and initial stability of implants.
钛植入物的骨整合对于牙科和医学植入物的成功都很重要。先前的研究试图通过考虑使用等离子体射流技术来改善骨整合，但仍缺乏与动物模型以及骨整合相关参数的信息。因此，本研究在杂种犬中研究了非热大气压力等离子体射流（NTAPPJ）处理对钛植入物骨整合的影响。总共41枚植入物；21枚经NTAPPJ处理，20枚为对照，被植入6只杂种犬的上颌和下颌，放置4周或8周。通过感兴趣区域（ROI）确定骨体积（BV）和骨与植入物接触（BIC）比率。采用Wilcoxon秩和检验进行统计分析。与对照组相比，NTAPPJ组在4周时的BV和BIC均较高（<0.05）。然而，在8周时，对照组和实验组之间的差异不太显著，因为对照组已赶上实验组。因此，NTAPPJ可能是对初始愈合期有效的治疗方法，这对于确保可靠的长期可预测性至关重要。临床已证明，使用NTAPPJ可在初始阶段加速BV和BIC，有助于植入物的愈合和初始稳定性。
