Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Mainz, Mainz, Germany.
Clin Oral Implants Res. 2010 Mar;21(3):350-6. doi: 10.1111/j.1600-0501.2009.01832.x. Epub 2010 Jan 13.
The aim of this study was to evaluate osseointegration of one-piece zirconia vs. titanium implants depending on their insertion depth by histomorphometry.
Four one-piece implants of identical geometry were inserted on each side of six mongrel dogs: (1) an uncoated zirconia implant, (2) a zirconia implant coated with a calcium-liberating titanium oxide coating, (3) a titanium implant and (4) an experimental implant made of a synthetic material (polyetheretherketone). In a split-mouth manner they were inserted in submerged and non-submerged gingival healing modes. After 4 months, dissected blocks were stained with toluidine blue in order to histologically assess the bone-to-implant contact (BIC) rates and the bone levels (BL) of the implants.
All 48 implants were osseointegrated clinically and histologically. Histomorphometrically, BL in the crestal implant part did not differ significantly with regard to material type or healing modality. The submerged coated zirconia implants tended to offer the most stable crestal BL. The histometric results reflected the different healing modes by establishing different BL. The median BIC of the apical implant part of the zirconia and titanium group amounted to 59.2% for uncoated zirconia, 58.3% for coated zirconia, 26.8% for the synthetic material and 41.2% for titanium implants.
Within the limits of this animal study, it is concluded that zirconia implants are capable of establishing close BIC rates similar to what is known from the osseointegration behaviour of titanium implants with the same surface modification and roughness.
本研究旨在通过组织形态计量学评估一体式氧化锆与钛种植体的骨整合情况及其与种植体植入深度的关系。
在 6 只杂种犬的每侧各植入 4 个具有相同几何形状的一体式种植体：（1）未涂层氧化锆种植体，（2）涂有释钙氧化钛涂层的氧化锆种植体，（3）钛种植体和（4）由合成材料（聚醚醚酮）制成的实验种植体。采用分侧方式，以龈下和非龈下愈合模式植入。4 个月后，用甲苯胺蓝对解剖块进行染色，以组织学评估种植体的骨-种植体接触率（BIC）和种植体的骨水平（BL）。
所有 48 个种植体均在临床和组织学上实现了骨整合。组织形态计量学上，在嵴顶种植体部分，材料类型或愈合方式与 BL 无显著差异。涂层氧化锆在龈下植入的种植体具有最稳定的嵴顶 BL。组织学结果通过建立不同的 BL 反映了不同的愈合模式。氧化锆和钛组根尖种植体部分的中位 BIC 为未涂层氧化锆 59.2%、涂层氧化锆 58.3%、合成材料 26.8%和钛种植体 41.2%。
在本动物研究的范围内，可以得出结论，氧化锆种植体能够建立类似于具有相同表面改性和粗糙度的钛种植体的骨整合行为的紧密 BIC 率。
