与感染呈正相关，是黏膜损伤的生物标志物。
is positively correlated with in infection and a biomarker for mucosal injury.
作者信息
Jinling Xie, Guoan Liu, Chuxi Chen, Qiaoyuan Liu, Yinzhong Chen, Shihao Chen, Huaquan Long, Yunxuan He, Yunshan Ning, Yan Li
机构信息
School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.
Xinhui District People's Hospital, Affiliated with the Southern Medical University, Jiangmen 529100, China.
出版信息
iScience. 2024 Jun 20;27(7):110323. doi: 10.1016/j.isci.2024.110323. eCollection 2024 Jul 19.
Our study previously showed the involvement of Notch1 in Th1 differentiation in -infected patients. However, the role of Notch1 in Th17 or Treg differentiation during infection and the potential diagnostic value of its associated genes remain unclear. Here, we found that was positively correlated with Th17-related genes ( = 0.616, < 0.001) and ( 0.523, < 0.01), but not with Treg-related genes and . The mRNA levels of aforementioned genes were upregulated at different stages of mucosal injury except for upper gastrointestinal ulcers. A combiROC analysis of and discriminated -infected gastritis from healthy controls with high accuracy (AUC of 0.952, sensitivity of 0.929, and specificity of 0.893). This study is the first to show that Notch1 is correlated with Th17-associated gene expression during infection. Additionally, and are potential diagnostic markers.
我们的研究先前表明，Notch1参与了感染患者的Th1分化。然而，Notch1在感染期间Th17或Treg分化中的作用及其相关基因的潜在诊断价值仍不清楚。在这里，我们发现与Th17相关基因（= 0.616，< 0.001）和（0.523，< 0.01）呈正相关，但与Treg相关基因和不相关。除上消化道溃疡外，上述基因的mRNA水平在黏膜损伤的不同阶段均上调。对和进行的combiROC分析能够高度准确地区分感染性胃炎与健康对照（曲线下面积为0.952，敏感性为0.929，特异性为0.893）。本研究首次表明，Notch1在感染期间与Th17相关基因表达相关。此外，和是潜在的诊断标志物。
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