Uehara A, Isaka Y, Hashikawa K, Kimura K, Kozuka T, Kamada T, Etani H, Yoneda S, Imaizumi M
First Department of Internal Medicine, Osaka University Medical School, Japan.
J Nucl Med. 1988 Jul;29(7):1264-7.
Fibronectin is known to interact with fibrin, collagen, etc. We have labeled fibronectin with 131I, and measured its accumulation in the deendothelialized lesion in the rabbit aorta to evaluate it as a candidate for imaging atherosclerotic lesions and thrombi. Accumulation of [131I] fibronectin in the deendothelialized lesion was apparent at 48 hr, and increased at 72 hr after injection of the agent. Our results indicate that radiolabeled fibronectin may be a useful tracer for imaging early atherosclerotic lesion and thrombus.
已知纤连蛋白可与纤维蛋白、胶原蛋白等相互作用。我们用131I标记了纤连蛋白，并测量其在兔主动脉去内皮损伤部位的蓄积情况，以评估其作为动脉粥样硬化病变和血栓成像候选物的可能性。在注射该试剂后48小时，[131I]纤连蛋白在去内皮损伤部位的蓄积明显，并在72小时时增加。我们的结果表明，放射性标记的纤连蛋白可能是用于早期动脉粥样硬化病变和血栓成像的有用示踪剂。
