Department of Pharmacy, School of Applied Sciences, University of Huddersfield, HD1 3DH, Huddersfield, UK.
Sci Rep. 2020 Apr 2;10(1):5814. doi: 10.1038/s41598-020-62795-1.
Although gastro-oesophageal reflux disease (GORD) is a common medical complaint, there is currently no consensus on the global prevalence of GORD. The aim of this study was to conduct a systematic review and meta-analysis on GORD prevalence and risk factors at a global level. MEDLINE, EMBASE, CINAHL, Scopus, Cochrane library, and Google Scholar were systematically searched, without language restrictions, for studies on the prevalence and risk factors of GORD. Data were pooled using a random effects model (95% confidence interval), and the odds ratio and relative risk for each risk factor were calculated. Out of 34,355 search results, 96 records reporting the results from 102 studies fulfilled the inclusion criteria, representing 37 countries and all regions of the UN geoscheme. The global pooled prevalence of GORD was 13.98% and varied greatly according to region (12.88% in Latin America and the Caribbean to 19.55% in North America) and country (4.16% in China to 22.40% in Turkey). Using the United Nations 2017 Revision of World Population Prospects, the estimated number of individuals suffering from GORD globally is 1.03 billion. Multiple risk factors associated with a significant increase in the risk of GORD were also identified. This systematic review and meta-analysis revealed that although a substantial proportion (13.98%) of the global population suffers from GORD, there are significant variations between regions and countries. Risk factors for GORD were also identified which may allow clinicians to recognise individuals most at risk.
尽管胃食管反流病（GORD）是一种常见的医学疾病，但目前全球 GORD 的患病率尚没有共识。本研究旨在对全球 GORD 的患病率和危险因素进行系统回顾和荟萃分析。系统检索了 MEDLINE、EMBASE、CINAHL、Scopus、Cochrane 图书馆和 Google Scholar，不限制语言，以获取关于 GORD 患病率和危险因素的研究。使用随机效应模型（95%置信区间）汇总数据，并计算每个危险因素的比值比和相对风险。在 34355 个搜索结果中，有 96 条记录报告了来自 102 项研究的结果，符合纳入标准，代表了 37 个国家和联合国地理方案的所有区域。全球 GORD 的总体患病率为 13.98%，根据区域（拉丁美洲和加勒比地区为 12.88%，北美为 19.55%）和国家（中国为 4.16%，土耳其为 22.40%）差异很大。根据联合国 2017 年世界人口展望修订版，全球患有 GORD 的人数估计为 10.3 亿。还确定了与 GORD 风险显著增加相关的多个危险因素。本系统回顾和荟萃分析显示，尽管全球相当大比例（13.98%）的人口患有 GORD，但区域和国家之间存在显著差异。还确定了 GORD 的危险因素，这可能使临床医生能够识别出最易患病的个体。
