Laboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d'Ascq, France.
PHYCELL-Laboratoire de Physiologie Cellulaire, INSERM U1003, University of Lille, 59655 Villeneuve d'Ascq, France.
Cells. 2021 Apr 26;10(5):1021. doi: 10.3390/cells10051021.
The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer. The great diversity of functions performed by these channels is represented by nine sub-families that constitute the TRP channel superfamily. From the mid-2000s, several reports have shown the potential role of the TRP channels in cancers of multiple origin. The pancreatic cancer is one of the deadliest cancers worldwide. Its prevalence is predicted to rise further. Disappointingly, the treatments currently used are ineffective. There is an urgency to find new ways to counter this disease and one of the answers may lie in the ion channels belonging to the superfamily of TRP channels. In this review, we analyse the existing knowledge on the role of TRP channels in the development and progression of pancreatic ductal adenocarcinoma (PDAC). The functions of these channels in other cancers are also considered. This might be of interest for an extrapolation to the pancreatic cancer in an attempt to identify potential therapeutic interventions.
瞬时受体电位通道（TRP）与多种不同的生理学有关，从感觉生理学（包括热和渗透压感觉）到某些病理学（如癌症）的作用。这些通道执行的功能多样性由构成 TRP 通道超家族的九个亚家族代表。从 21 世纪中期开始，有几项报告表明 TRP 通道在多种起源的癌症中具有潜在作用。胰腺癌是全球最致命的癌症之一。预计其患病率还会进一步上升。令人失望的是，目前使用的治疗方法效果不佳。迫切需要寻找新的方法来对抗这种疾病，而答案之一可能在于属于 TRP 通道超家族的离子通道。在这篇综述中，我们分析了 TRP 通道在胰腺导管腺癌（PDAC）发展和进展中的作用的现有知识。还考虑了这些通道在其他癌症中的功能。这可能对胰腺癌的推断具有重要意义，以试图确定潜在的治疗干预措施。
