中国河北发现两种新型 HIV-1 第二代重组形式（CRF01_AE/CRF07_BC）。
Identification of Two Novel HIV-1 Second-Generation Recombinant Forms (CRF01_AE/CRF07_BC) in Hebei, China.
机构信息
Department of Clinical Laboratory Medicine, Hebei Medical University, Shijiazhuang, China.
Department of Laboratory medicine, the Fifth Hospital of Shijiazhuang, Hebei Medicine University, Shijiazhuang, China.
出版信息
AIDS Res Hum Retroviruses. 2021 Dec;37(12):967-972. doi: 10.1089/AID.2021.0057. Epub 2021 May 26.
Homosexual contact is one of the main transmission routes of HIV-1 epidemic in Hebei, China. Several subtypes of HIV are prevalent simultaneously in the population, which always lead to the emergency of unique recombinant forms (URFs). In this study, we reported two new URFs from two HIV-1 positive subjects infected through homosexual contact route in Hebei, China. Phylogenetic and recombinant analyses based on the near full-length genome of the two URFs both revealed the two URFs are the second generation of recombinant strains originated from CRF01_AE and CRF07_BC. The CRF01_AE segments of two URFs located in cluster 4 of CRF01_AE strains in the phylogenetic tree. The emergence of the novel CRF01_AE/CRF07_BC recombinant forms with complicated genomic structures indicated the importance of the continuous monitoring of the HIV-1 epidemic and new URFs among the men who have sex with men populations.
同性恋接触是中国河北 HIV-1 流行的主要传播途径之一。人群中同时流行着几种 HIV 亚型，这往往会导致独特重组形式（URF）的出现。在这项研究中，我们报道了来自中国河北两名通过同性恋接触途径感染的 HIV-1 阳性个体的两种新的 URF。基于这两种 URF 的近乎全长基因组的系统发育和重组分析均表明，这两种 URF 是源自 CRF01_AE 和 CRF07_BC 的第二代重组株。两种 URF 的 CRF01_AE 片段在系统发育树中位于 CRF01_AE 株的簇 4 中。新型 CRF01_AE/CRF07_BC 重组形式的出现具有复杂的基因组结构，表明有必要对男男性行为人群中的 HIV-1 流行和新的 URF 进行持续监测。
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