Afsar Mohammed, Shukla Dhaval, Bhaskarapillai Binukumar, Rajeswaran Jamuna
Department of Clinical Psychology, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.
Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.
J Neurosci Rural Pract. 2021 Apr;12(2):295-301. doi: 10.1055/s-0041-1722817. Epub 2021 Apr 13.
Traumatic brain injury (TBI) is a leading cause of mortality and chronic disability across the globe. This study aimed to understand the effects of cognitive retraining (CR) intervention on neuropsychological functions, symptom reporting, and quality of life in patients with moderate to severe TBI. The present single-group intervention study with a pre-post design included 12 patients diagnosed with moderate to severe TBI within 3-24 months post injury. Outcome measures included National Institute of Mental Health and Neuro Sciences (NIMHANS) Neuropsychology Battery, Perceived Stress Scale, Rivermead Post-Concussion Symptom Questionnaire, World Health Organization Quality of Life Scale-Brief, and Visual Analogue Scale. All patients underwent a total of 20 sessions of hospital-based CR, spanning over a period of 2 months. The CR included tasks targeting to enhance processing speed, attention, executive function, learning, and memory. Outcome assessments were conducted at baseline and immediately at post intervention. Mean, standard deviation, frequency, and percentage were used as measures of descriptive statistics. Pre- and post-intervention scores were compared using Wilcoxon signed-rank test. The results showed that at post intervention, significant improvements were found in processing speed, working memory, planning, visuo-spatial construction, visual memory, and verbal encoding. Subjective symptom reporting, perceived stress, and quality of life in psychological domain also improved. CR can be helpful in improving not only cognition but also symptom reporting and quality of life in moderate to severe TBI.
创伤性脑损伤（TBI）是全球范围内导致死亡和慢性残疾的主要原因。本研究旨在了解认知康复（CR）干预对中重度TBI患者神经心理功能、症状报告和生活质量的影响。 本项采用前后设计的单组干预研究纳入了12例在受伤后3至24个月内被诊断为中重度TBI的患者。结局指标包括国家心理健康和神经科学研究所（NIMHANS）神经心理成套测验、感知压力量表、Rivermead脑震荡后症状问卷、世界卫生组织生活质量量表简表和视觉模拟量表。所有患者总共接受了为期2个月的20次基于医院的CR治疗。CR包括旨在提高处理速度、注意力、执行功能、学习和记忆的任务。在基线和干预后立即进行结局评估。 均值、标准差、频率和百分比用作描述性统计量度。使用Wilcoxon符号秩检验比较干预前后的分数。 结果表明，干预后，在处理速度、工作记忆、计划、视觉空间构建、视觉记忆和言语编码方面发现了显著改善。主观症状报告、感知压力和心理领域的生活质量也有所改善。 CR不仅有助于改善中重度TBI患者的认知，还有助于改善症状报告和生活质量。
