连接1,2,3-三唑的1,8-萘二甲酰亚胺衍生物的合成与抗肿瘤活性
The Synthesis and Antitumor Activity of 1,8-Naphthalimide Derivatives Linked 1,2,3-Triazole.
作者信息
Xu Zhong-Jie, Zhou Ying-Jie, Wang Jia-Hao, Mao Long-Fei, Li Wei, Xu Gui-Qing
机构信息
College of Life Science and Technology, Xinxiang Medical University, Xinxiang, China.
Henan Engineering Research Center of Chiral Hydroxyl Pharmaceutical, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China.
出版信息
Front Bioeng Biotechnol. 2021 Apr 13;9:662432. doi: 10.3389/fbioe.2021.662432. eCollection 2021.
In this study, acenaphthylene was used as the raw material, and a series of novel 1,8-naphthalimide-1,2,3-triazole derivatives was obtained through oxidation, acylation, alkylation, and click reactions, and subsequently, their anti-tumor activities were tested. After screening, we found that Compound showed good activity against H1975 lung cancer cells, with the half maximal inhibitory concentration (IC) reaching 16.56 μM.
在本研究中，以苊为原料，通过氧化、酰化、烷基化和点击反应得到了一系列新型的1,8-萘二甲酰亚胺-1,2,3-三唑衍生物，随后测试了它们的抗肿瘤活性。筛选后，我们发现化合物对H1975肺癌细胞表现出良好的活性，半数抑制浓度（IC）达到16.56 μM。
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