Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
J Ind Microbiol Biotechnol. 2021 Jun 4;48(3-4). doi: 10.1093/jimb/kuab002.
Terpenoids are one of the largest classes of natural products whose members possess a wide variety of biological activities. With several exceptions, scalable production of complex terpenoids with either purely biological or chemical methods still remains a major challenge. However, recent efforts to combine the two approaches in chemoenzymatic synthesis hold tremendous promise to address this challenge. Central to this paradigm is the development of useful biocatalytic methods, such as regioselective C-H oxidation, for terpene modifications. This review highlights recent applications of biocatalytic hydroxylation for site-selective modification of terpenoids.
萜类化合物是最大的天然产物类别之一，其成员具有广泛的生物活性。除了几种例外情况外，用纯生物或化学方法规模化生产复杂萜类化合物仍然是一个主要挑战。然而，最近将这两种方法结合在化学酶合成中的努力为解决这一挑战带来了巨大的希望。这一范例的核心是开发有用的生物催化方法，如区域选择性 C-H 氧化，用于萜类化合物的修饰。本文综述了生物催化羟化在萜类化合物的选择性修饰中的最新应用。
