Afyonkarahisar Health Sciences University Faculty of Medicine, Department of Radiology, Afyonkarahisar, Turkey.
Eur Rev Med Pharmacol Sci. 2021 Apr;25(8):3254-3263. doi: 10.26355/eurrev_202104_25734.
To test the correlation between the visual semi-quantitative score (VSQS) and different quantitative computed tomography (QCT) analyses and pulmonary physiology variables, and to determine the performance of these types of analyses on the Gender, Age, and Physiology (GAP) model for the prediction of mortality risk of idiopathic pulmonary fibrosis (IPF).
High-resolution computed tomography (HRCT) images of IPF patients were reviewed and the VSQS was calculated. Evaluations were made of the QCT score of interstitial lung disease (ILD) using four different previously defined methods. Respiratory function tests (RFT) and the 6-minute walk test (6MWT) were applied to all the patients. The GAP model was used to evaluate the mortality risk. The performance of the VSQS score and QCT methods on the GAP model to predict the mortality risk of the disease was calculated with ROC analysis.
The study included 40 patients who met the criteria. A statistically significant correlation was determined between all the quantitative and semi-quantitative measurement results (p<0.001). A significant correlation was determined between the VSQS and QCT parameters and the RFT and 6MWT. In the ROC analysis, method 4 of the QCT parameters (a value of the voxels between -700 and -950 HU) and the VSQS showed the best performance in the differentiation of stage I, stage II, and stage III, according to the GAP model.
The selection of a quantitative method was useful in the evaluation of spread in patients with IPF. According to the GAP model, VSQS performed best in predicting mortality risk. Furthermore, method 4 of the QCT parameters, which shows well-aerated lungs, were deemed to have good potential for the estimation of mortality risk.
检验视觉半定量评分（VSQS）与不同定量计算机断层扫描（QCT）分析及肺生理学变量之间的相关性，并确定这些分析方法在用于预测特发性肺纤维化（IPF）患者死亡率的性别、年龄和生理学（GAP）模型中的表现。
回顾 IPF 患者的高分辨率计算机断层扫描（HRCT）图像并计算 VSQS。使用四种先前定义的方法评估间质肺病（ILD）的 QCT 评分。对所有患者进行呼吸功能测试（RFT）和 6 分钟步行测试（6MWT）。应用 GAP 模型评估死亡率。采用 ROC 分析计算 VSQS 评分和 QCT 方法在 GAP 模型上对疾病死亡率预测的性能。
研究纳入了符合标准的 40 名患者。所有定量和半定量测量结果之间存在统计学显著相关性（p<0.001）。VSQS 与 QCT 参数以及 RFT 和 6MWT 之间存在显著相关性。在 ROC 分析中，QCT 参数的方法 4（-700 至-950 HU 之间的体素值）和 VSQS 在根据 GAP 模型区分 I 期、II 期和 III 期时表现最佳。
定量方法的选择有助于评估 IPF 患者的病变范围。根据 GAP 模型，VSQS 在预测死亡率风险方面表现最佳。此外，QCT 参数的方法 4 显示出良好的充气肺，被认为对死亡率风险的估计具有良好的潜力。
