Institute for Neurodegenerative Diseases (IND), Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158, United States.
Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158, United States.
Org Lett. 2021 May 21;23(10):3823-3827. doi: 10.1021/acs.orglett.1c00871. Epub 2021 Apr 30.
The development of a water-soluble iridium catalyst enables the trifluoromethylation of polar small molecules and peptides in DMSO solution or aqueous media. The reaction was optimized in a microtiter plate format under ambient air, using commercial Langlois reagent as a CF radical source, blue LEDs for excitation, and using DPBS as solvent to provide up to 60% CF- peptide.
一种水溶性铱催化剂的开发使得在 DMSO 溶液或水介质中可以对极性小分子和肽进行三氟甲基化。该反应在环境空气中采用微量滴定板格式进行优化，使用商业 Langlois 试剂作为 CF 自由基源、蓝色 LED 激发，并使用 DPBS 作为溶剂，可得到高达 60%的 CF-肽。
