Department of Ophthalmology, First Affiliated Hospital of Jinan University, Guangzhou, China.
Int Ophthalmol. 2021 Sep;41(9):3249-3256. doi: 10.1007/s10792-021-01873-3. Epub 2021 Apr 30.
The aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years.
We performed literature review of articles published on PubMed, Google Scholar, CNKI and Web of Science relevant to the diagnosis, pathogenesis and novel treatment of fungal keratitis.
Excessive inflammation can lead to stromal damage and corneal opacification, hence the research on immune mechanism provides many potential therapeutic targets for fungal keratitis. Many researchers discussed the importance of earlier definitive diagnosis and were trying to find rapid and accurate diagnostic methods of pathogens. Develop new drug delivery systems and new routes of administration with better corneal penetration, prolonged ocular residence time, and better mucoadhesive properties is also one of the research hotspots. Additionally, many novel therapeutic agents and methods have been gradually applied in clinical ophthalmology.
The diagnosis and treatment of fungal keratitis are still a challenge for ophthalmologist, and many researches provide new methods to conquer these problems.
本文旨在介绍过去 5 年来关于真菌性角膜炎研究的最新进展。
我们对 PubMed、Google Scholar、CNKI 和 Web of Science 上发表的与真菌性角膜炎的诊断、发病机制和新治疗方法相关的文章进行了文献回顾。
过度炎症可导致基质损伤和角膜混浊，因此免疫机制的研究为真菌性角膜炎提供了许多潜在的治疗靶点。许多研究人员讨论了早期明确诊断的重要性，并试图寻找病原体的快速、准确诊断方法。开发具有更好角膜穿透性、更长眼内滞留时间和更好黏膜附着性的新型药物递送系统和新给药途径也是研究热点之一。此外，许多新型治疗药物和方法已逐渐应用于临床眼科。
真菌性角膜炎的诊断和治疗仍然是眼科医生面临的挑战，许多研究为解决这些问题提供了新的方法。
