Symbiosis Centre for Stem Cell Research, Symbiosis International University, Pune, 412115, India.
Symbiosis Centre for Stem Cell Research, Symbiosis International University, Pune, 412115, India.
Reprod Biol. 2021 Jun;21(2):100508. doi: 10.1016/j.repbio.2021.100508. Epub 2021 Apr 27.
Stem cell therapy has gained much impetus in regenerative medicine due to some of the encouraging results obtained in the laboratory as well as in translational/clinical studies. Although stem cells are of various types and their therapeutic potential has been documented in several studies, mesenchymal stromal/stem cells (MSCs) have an edge, as in addition to being multipotent, these cells are easy to obtain and expand, pose fewer ethical issues, and possess immense regenerative potential when used in a scientifically correct manner. Currently, MSCs are being sourced from various tissues such as bone marrow, cord, cord blood, adipose tissue, dental tissue, etc., and, quite often, the choice depends on the availability of the source. One such rich source of tissue suitable for obtaining good quality MSCs in large numbers is the placenta obtained in a full-term delivery leading to a healthy child's birth. Several studies have demonstrated the regenerative potential of human placenta-derived MSCs (hPMSC), and most show that these MSCs possess comparable, in some instances, even better, therapeutic potential as that shown by human bone marrow-derived (hBMSC) or human umbilical cord-derived (hUC-MSC) MSCs. The placenta can be easily sourced from the OB/GYN department of any hospital, and if its derivatives such as hPMSC or their EVs are produced under GMP conditions, it could serve as a gold mine for translational/clinical research. Here, we have reviewed recent studies revealing the therapeutic potential of hPMSC and their extracellular vesicles (EVs) published over the past three years.
干细胞疗法在再生医学中得到了很大的推动，这是因为在实验室以及转化/临床研究中获得了一些令人鼓舞的结果。虽然干细胞有多种类型，并且在许多研究中已经证明了它们的治疗潜力，但间充质基质/干细胞（MSCs）具有优势，因为除了多能性之外，这些细胞易于获得和扩增，引起的伦理问题较少，并且以科学正确的方式使用时具有巨大的再生潜力。目前，MSCs 来源于各种组织，如骨髓、脐带、脐带血、脂肪组织、牙组织等，并且，选择通常取决于来源的可用性。胎盘是一种适合大量获得高质量 MSCs 的丰富组织来源，它是在足月分娩后获得的，从而诞生了健康的孩子。许多研究已经证明了人胎盘来源的间充质干细胞（hPMSC）的再生潜力，并且大多数研究表明，这些 MSC 具有可比较的，在某些情况下甚至更好的治疗潜力，与人类骨髓来源的（hBMSC）或人类脐带来源的（hUC-MSC）MSC 相当。胎盘可以很容易地从任何医院的妇产科获得，如果其衍生物（如 hPMSC 或它们的 EV）在 GMP 条件下生产，则可以作为转化/临床研究的宝库。在这里，我们回顾了过去三年发表的关于 hPMSC 及其细胞外囊泡（EV）的治疗潜力的最新研究。
