头颈部癌中肿瘤间质比的临床意义：系统评价和荟萃分析。
Clinical significance of tumor-stroma ratio in head and neck cancer: a systematic review and meta-analysis.
机构信息
Department of Pathology, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, Helsinki, Finland.
Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
出版信息
BMC Cancer. 2021 Apr 30;21(1):480. doi: 10.1186/s12885-021-08222-8.
BACKGROUND
The clinical significance of tumor-stroma ratio (TSR) has been examined in many tumors. Here we systematically reviewed all studies that evaluated TSR in head and neck cancer.
METHODS
Four databases (Scopus, Medline, PubMed and Web of Science) were searched using the term tumo(u)r-stroma ratio. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were followed.
RESULTS
TSR was studied in nine studies of different subsites (including cohorts of nasopharyngeal, oral, laryngeal and pharyngeal carcinomas). In all studies, TSR was evaluated using hematoxylin and eosin staining. Classifying tumors based on TSR seems to allow for identification of high-risk cases. In oral cancer, specifically, our meta-analysis showed that TSR is significantly associated with both cancer-related mortality (HR 2.10, 95%CI 1.56-2.84) and disease-free survival (HR 1.84, 95%CI 1.38-2.46).
CONCLUSIONS
The assessment of TSR has a promising prognostic value and can be implemented with minimum efforts in routine head and neck pathology.
背景
肿瘤间质比（TSR）在许多肿瘤中的临床意义已被研究。在这里，我们系统地回顾了所有评估头颈部癌症 TSR 的研究。
方法
使用术语 tumo(u)r-stroma ratio 在四个数据库（Scopus、Medline、PubMed 和 Web of Science）中进行搜索。遵循系统评价和荟萃分析的首选报告项目（PRISMA）。
结果
TSR 在不同部位（包括鼻咽癌、口腔癌、喉癌和咽癌队列）的九项研究中进行了研究。在所有研究中，均使用苏木精和伊红染色评估 TSR。根据 TSR 对肿瘤进行分类似乎可以识别高危病例。具体来说，我们的荟萃分析表明，在口腔癌中，TSR 与癌症相关死亡率（HR 2.10，95%CI 1.56-2.84）和无病生存率（HR 1.84，95%CI 1.38-2.46）显著相关。
结论
评估 TSR 具有有前途的预后价值，可以在头颈部病理常规中以最小的努力实施。
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