Department of Dermatology, George Washington University School of Medicine, Washington, District of Columbia, USA.
Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Contact Dermatitis. 2021 Oct;85(4):435-445. doi: 10.1111/cod.13877. Epub 2021 May 19.
Little is known about the relationship between psoriasis and allergic contact dermatitis (ACD).
To examine the associations with ACD, related clinical characteristics, and common positive and clinically relevant allergens of patients with a final diagnosis of psoriasis who were referred for patch testing.
Retrospective analysis of 38 723 patients from the North American Contact Dermatitis Group.
Patients with a final diagnosis of psoriasis had lower proportions of ACD than those without psoriasis (32.7% vs 57.8%). In multivariable logistic regression models, psoriasis was inversely associated with female sex, Black or Asian race, and history of atopic dermatitis and hay fever. Patients with a final diagnosis of psoriasis were less likely to have one or more positive allergic patch-test reactions or to have a current clinically relevant patch-test reaction to the majority of the most commonly positive and/or relevant allergens. The most clinically relevant allergens included nickel sulfate, methylisothiazolinone, and fragrance mix I.
Approximately one-third of patients who were referred for patch testing with a final diagnosis of psoriasis were also diagnosed with ACD. In select patients with suspected psoriasis who also have a clinical presentation suggestive of ACD, patch testing may be helpful.
关于银屑病与过敏性接触性皮炎（ACD）之间的关系知之甚少。
探讨确诊为银屑病患者的 ACD 关联性、相关临床特征以及常见阳性和临床相关变应原。
对北美接触性皮炎组的 38723 例患者进行回顾性分析。
确诊为银屑病的患者 ACD 比例低于未患银屑病的患者（32.7%比 57.8%）。在多变量逻辑回归模型中，银屑病与女性、黑人和亚裔、特应性皮炎和花粉热病史呈负相关。确诊为银屑病的患者更不可能出现一个或多个阳性过敏斑贴试验反应，也更不可能对大多数最常见的阳性和/或相关变应原出现当前临床相关斑贴试验反应。最具临床相关性的变应原包括硫酸镍、甲基异噻唑啉酮和香料混合物 I。
大约三分之一因确诊为银屑病而接受斑贴试验的患者也被诊断为 ACD。对于疑似银屑病且临床表现提示存在 ACD 的特定患者，斑贴试验可能会有所帮助。
