Wang Li, Li Qianqian, Hu Jie, Luo Ronghua, Duan Yaping, Ai Tao
Pediatric Respiratory Medicine Department, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Front Pediatr. 2025 Jan 6;12:1443877. doi: 10.3389/fped.2024.1443877. eCollection 2024.
infection accounts for a high proportion of community-acquired pneumonia and the incidence rate of severe pneumonia (MPP) has increased year by year. This study investigated the changes in lung diffusion function after infection, compared the lung diffusion and ventilation function of children with mild (MMPP) or severe pneumonia (SMPP) infections, and explored their clinical significance.
To study the changes in pulmonary ventilation and pulmonary diffusion function in children with MPP, and explore their clinical significance.
Data from 97 children with pneumonia hospitalized in Chengdu Women and Children's Central Hospital from June 2023 to December 2023 were collected and the participants were divided into an MMPP group ( = 44) and an SMPP group ( = 53). The changes in pulmonary ventilation function and diffusion function were compared between the two groups.
The -scores of forced vital capacity and forced expiratory volume in the first second in the SMPP and MMPP groups were -1.684 ± 0.902 and -1.986 ± 0.818, and 0.164 ± 1.795 and -0.6104 ± 1.276, respectively. In the SMPP group, the two aforementioned indicators were lower than the normal value and significantly lower than those in the MMPP group ( < 0.001). The carbon monoxide diffusion capacity in the SMPP group (-5.931 ± 0.827) was significantly lower than that in the MMPP group (-5.0775 ± 1.1134) ( < 0.001). The forced expiratory flow at 75% vital capacity and the maximum mid expiratory flow in the SMPP group were -2.006 ± 1.2582 and -1.878 ± 1.008, respectively, which were lower than the normal value.
SMPP results in more severe ventilation dysfunction and diffuse dysfunction than MMPP.
感染在社区获得性肺炎中占比很高，重症肺炎（MPP）的发病率逐年上升。本研究调查了感染后肺弥散功能的变化，比较了轻度（MMPP）或重症肺炎（SMPP）感染儿童的肺弥散和通气功能，并探讨其临床意义。
研究MPP患儿肺通气和肺弥散功能的变化，并探讨其临床意义。
收集2023年6月至2023年12月在成都市妇女儿童中心医院住院的97例肺炎患儿的数据，并将参与者分为MMPP组（n = 44）和SMPP组（n = 53）。比较两组肺通气功能和弥散功能的变化。
SMPP组和MMPP组的用力肺活量和第一秒用力呼气量的z评分分别为-1.684±0.902和-1.986±0.818，以及0.164±1.795和-0.6104±1.276。在SMPP组中，上述两个指标均低于正常值，且显著低于MMPP组（P < 0.001）。SMPP组的一氧化碳弥散量（-5.931±0.827）显著低于MMPP组（-5.0775±1.1134）（P < 0.001）。SMPP组75%肺活量时的用力呼气流量和最大呼气中期流量分别为-2.006±1.2582和-1.878±1.008，均低于正常值。
与MMPP相比，SMPP导致更严重的通气功能障碍和弥散功能障碍。
