Department of Otorhinolaryngology (ENT), Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Netherlands Institute for Health Sciences, Erasmus University Medical Center, Rotterdam, The Netherlands.
Value Health. 2021 May;24(5):648-657. doi: 10.1016/j.jval.2020.12.010. Epub 2021 Mar 5.
Coronavirus disease 2019 has put unprecedented pressure on healthcare systems worldwide, leading to a reduction of the available healthcare capacity. Our objective was to develop a decision model to estimate the impact of postponing semielective surgical procedures on health, to support prioritization of care from a utilitarian perspective.
A cohort state-transition model was developed and applied to 43 semielective nonpediatric surgical procedures commonly performed in academic hospitals. Scenarios of delaying surgery from 2 weeks were compared with delaying up to 1 year and no surgery at all. Model parameters were based on registries, scientific literature, and the World Health Organization Global Burden of Disease study. For each surgical procedure, the model estimated the average expected disability-adjusted life-years (DALYs) per month of delay.
Given the best available evidence, the 2 surgical procedures associated with most DALYs owing to delay were bypass surgery for Fontaine III/IV peripheral arterial disease (0.23 DALY/month, 95% confidence interval [CI]: 0.13-0.36) and transaortic valve implantation (0.15 DALY/month, 95% CI: 0.09-0.24). The 2 surgical procedures with the least DALYs were placing a shunt for dialysis (0.01, 95% CI: 0.005-0.01) and thyroid carcinoma resection (0.01, 95% CI: 0.01-0.02).
Expected health loss owing to surgical delay can be objectively calculated with our decision model based on best available evidence, which can guide prioritization of surgical procedures to minimize population health loss in times of scarcity. The model results should be placed in the context of different ethical perspectives and combined with capacity management tools to facilitate large-scale implementation.
2019 年冠状病毒病给全球医疗体系带来了前所未有的压力,导致可用医疗能力下降。我们的目的是开发一种决策模型来估计推迟半选择性手术对健康的影响,从功利主义的角度支持医疗护理的优先级排序。
开发了一个队列状态转移模型,并将其应用于在学术医院中常见的 43 种半选择性非儿科手术。将手术推迟 2 周与推迟长达 1 年和不进行手术的情况进行了比较。模型参数基于注册、科学文献和世界卫生组织全球疾病负担研究。对于每种手术,该模型估计了每个月因延迟而导致的平均预期残疾调整生命年(DALY)。
根据最佳现有证据,由于延迟而导致的 DALY 最多的 2 种手术是 Fontaine III/IV 外周动脉疾病的旁路手术(0.23 DALY/月,95%置信区间 [CI]:0.13-0.36)和经主动脉瓣植入术(0.15 DALY/月,95% CI:0.09-0.24)。导致 DALY 最少的 2 种手术是为透析放置分流器(0.01,95% CI:0.005-0.01)和甲状腺癌切除术(0.01,95% CI:0.01-0.02)。
根据我们基于最佳现有证据的决策模型,可以客观地计算出因手术延迟而导致的预期健康损失,这可以指导手术优先级排序,以最大限度地减少资源匮乏时期的人群健康损失。模型结果应置于不同的伦理视角下,并与能力管理工具相结合,以促进大规模实施。