棕色脂肪组织的昼夜节律控制。
Circadian control of brown adipose tissue.
机构信息
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.
出版信息
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158961. doi: 10.1016/j.bbalip.2021.158961. Epub 2021 Apr 30.
Disruption of circadian (~24 h) rhythms is associated with an increased risk of cardiometabolic diseases. Therefore, unravelling how circadian rhythms are regulated in different metabolic tissues has become a prominent research focus. Of particular interest is brown adipose tissue (BAT), which combusts triglyceride-derived fatty acids and glucose into heat and displays a circannual and diurnal rhythm in its thermogenic activity. In this review, the genetic, neuronal and endocrine generation of these rhythms in BAT is discussed. In addition, the potential risks of disruption or attenuation of these rhythms in BAT, and possible factors influencing these rhythms, are addressed.
昼夜节律（约 24 小时）的破坏与心血管代谢疾病风险的增加有关。因此，揭示不同代谢组织中昼夜节律的调节机制已成为一个突出的研究重点。特别引人关注的是棕色脂肪组织（BAT），它能将甘油三酯衍生的脂肪酸和葡萄糖转化为热量，并在其产热活性中表现出年节律和日节律。在这篇综述中，讨论了 BAT 中这些节律的遗传、神经元和内分泌产生。此外，还讨论了 BAT 中这些节律的破坏或衰减的潜在风险，以及可能影响这些节律的因素。
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