昼夜节律钟与皮肤疾病。
The circadian clock and diseases of the skin.
机构信息
Center for Complex Biological Systems, University of California, Irvine, CA, USA.
Department of Biological Chemistry, University of California, Irvine, CA, USA.
出版信息
FEBS Lett. 2021 Oct;595(19):2413-2436. doi: 10.1002/1873-3468.14192. Epub 2021 Sep 29.
Organisms have an evolutionarily conserved internal rhythm that helps them anticipate and adapt to daily changes in the environment. Synchronized to the light-dark cycle with a period of around 24 hours, the timing of the circadian clock is set by light-triggering signals sent from the retina to the suprachiasmatic nucleus. Other inputs, including food intake, exercise, and temperature, also affect clocks in peripheral tissues, including skin. Here, we review the intricate interplay between the core clock network and fundamental physiological processes in skin such as homeostasis, regeneration, and immune- and stress responses. We illustrate the effect of feeding time on the skin circadian clock and skin functions, a previously overlooked area of research. We then discuss works that relate the circadian clock and its disruption to skin diseases, including skin cancer, sunburn, hair loss, aging, infections, inflammatory skin diseases, and wound healing. Finally, we highlight the promise of circadian medicine for skin disease prevention and management.
生物体内有一种进化上保守的内部节律，帮助它们预测和适应环境中日常的变化。生物钟的时间与大约 24 小时的光暗周期同步，由从视网膜发送到视交叉上核的光触发信号设定。其他输入，包括食物摄入、运动和温度，也会影响包括皮肤在内的外周组织中的时钟。在这里，我们综述了核心时钟网络与皮肤中基本生理过程（如稳态、再生以及免疫和应激反应）之间错综复杂的相互作用。我们举例说明了进食时间对皮肤生物钟和皮肤功能的影响，这是一个以前被忽视的研究领域。然后，我们讨论了与皮肤疾病相关的时钟及其紊乱的相关研究，包括皮肤癌、晒伤、脱发、衰老、感染、炎症性皮肤病和伤口愈合。最后，我们强调了生物钟医学在皮肤疾病预防和管理方面的应用前景。
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