Bautista Jhommara, Ojeda-Mosquera Sofía, Ordóñez-Lozada Dylan, López-Cortés Andrés
Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
Facultade de Ciencias, Campus de A Zapateira, Universidade da Coruña, A Coruña, Spain.
Front Endocrinol (Lausanne). 2025 May 29;16:1606242. doi: 10.3389/fendo.2025.1606242. eCollection 2025.
Circadian rhythms orchestrate nearly every aspect of human physiology through a hierarchical network of clocks. While the suprachiasmatic nucleus (SCN) serves as the central pacemaker, peripheral clocks within the brain, heart, liver, gut, pancreas, adipose tissue, adrenal glands, lungs, and skeletal muscle independently regulate organ-specific functions. These autonomous oscillators, governed by transcriptional-translational feedback loops of core clock genes, align with environmental and physiological such as light, feeding, temperature, and hormones. Disruption of this temporal organization-through shift work, genetic alterations, or lifestyle factors-drives systemic misalignment, contributing to metabolic disease, cardiovascular dysfunction, neurodegeneration, cancer, and immune imbalance. This review explores the molecular mechanisms and physiological roles of peripheral clocks across organ systems, emphasizing their interplay with the SCN and . We also highlight emerging chronotherapeutic strategies that exploit circadian biology to optimize treatment outcomes. Understanding inter-organ circadian communication is key to unlocking personalized interventions and restoring systemic rhythmicity for health.
昼夜节律通过一个分级时钟网络协调人类生理学的几乎每个方面。虽然视交叉上核（SCN）作为中央起搏器，但大脑、心脏、肝脏、肠道、胰腺、脂肪组织、肾上腺、肺和骨骼肌中的外周时钟独立调节器官特异性功能。这些自主振荡器由核心时钟基因的转录-翻译反馈环控制，与环境和生理因素（如光、进食、温度和激素）保持一致。通过轮班工作、基因改变或生活方式因素破坏这种时间组织会导致全身失调，从而引发代谢疾病、心血管功能障碍、神经退行性变、癌症和免疫失衡。本综述探讨了跨器官系统外周时钟的分子机制和生理作用，强调了它们与SCN的相互作用以及……我们还强调了新兴的时辰治疗策略，这些策略利用昼夜节律生物学来优化治疗效果。理解器官间的昼夜通讯是解锁个性化干预措施和恢复全身节律以促进健康的关键。
