College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Sci Total Environ. 2021 Sep 1;785:147365. doi: 10.1016/j.scitotenv.2021.147365. Epub 2021 Apr 27.
Plastics are widely used in many fields due to their stable physical and chemical properties, and their global production and usage increase significantly every year, which leads to the accumulation of microplastics in the entire ecosystem. Numerous studies have shown that microplastics (MPs) have harmful effects on living organisms. This review aims to provide a comprehensive conclusion of the current knowledge of the impacts of MPs on the stability of the gut microenvironment, especially on the gut barrier. Studies showed that exposure to MPs could cause oxidative damage and inflammation in the gut, as well as the destruction of the gut epithelium, reduction of the mucus layer, microbial disorders, and immune cell toxicity. Although there are few reports directly related to humans, we hoped that this review could bring together more and more evidence that exposure to MPs results in disturbances of the intestinal microenvironment. Therefore, it is necessary to investigate their threats to human health further.
由于其稳定的物理和化学性质，塑料在许多领域得到了广泛的应用，并且它们的全球产量和用量每年都在显著增加，这导致了微塑料在整个生态系统中的积累。大量研究表明，微塑料（MPs）对生物体有有害影响。本综述旨在对 MPs 对肠道微环境稳定性，特别是对肠道屏障的影响的现有知识进行全面总结。研究表明，暴露于 MPs 可导致肠道的氧化损伤和炎症，以及肠道上皮的破坏、黏液层减少、微生物紊乱和免疫细胞毒性。虽然直接与人类相关的报道很少，但我们希望本综述能够汇集越来越多的证据，证明暴露于 MPs 会导致肠道微环境紊乱。因此，有必要进一步研究它们对人类健康的威胁。
