ANO5在膜修复中的作用——现状：“情况复杂”
ANO5 in membrane repair - Status: "It's complicated".
作者信息
Gerke Volker, Rescher Ursula
机构信息
Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation (ZMBE) and Cells in Motion Interfaculty Center (CiM), University of Muenster, Muenster, Germany.
Research Group Regulatory Mechanisms of Inflammation, Center for Molecular Biology of Inflammation (ZMBE) and Cells in Motion Interfaculty Center (CiM), University of Muenster, Muenster, Germany.
出版信息
Cell Calcium. 2021 Jul;97:102415. doi: 10.1016/j.ceca.2021.102415. Epub 2021 Apr 27.
ANO5/TMEM16E gene mutations are associated with myopathies. Two recent publications in the Journal of Cell Biology now both confirm that ANO5 deficiency results in defective plasma membrane repair and Ca overload. But the big question is whether ANO5 acts at the plasma membrane or the endoplasmic reticulum.
ANO5/TMEM16E基因突变与肌病相关。《细胞生物学杂志》最近发表的两篇论文均证实，ANO5缺乏会导致质膜修复缺陷和钙超载。但最大的问题是ANO5是作用于质膜还是内质网。
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