Pin I, Pincemaille O, Jouk P S, Bost M
Service de médecine infantile, CHRG, Grenoble, France.
Pediatrie. 1988;43(2):109-15.
Thirty-two children were treated with nebulized salbutamol for acute asthma. Seventy-five per cent of the treatments were efficient, either after a first nebulization at 0.15 mg/kg (47% = group I), or after a second nebulization 45 min later, at 0.05 mg/kg (27% = group II). Twenty-five per cent of the treatments (group III) were inefficient or only partly efficient. The clinical tolerance was good except in two children. Group I and II presented differences only for the auscultation score. Children from group I and II were older and had less severe asthma than those from group III. On the basis of this study, nebulized salbutamol appears to be an affective and safe treatment for acute asthma. The repeated administration of low doses, shortly after the first nebulization increases the quality of the response.
32名儿童接受了雾化沙丁胺醇治疗急性哮喘。75%的治疗有效，其中47%（第一组）在首次以0.15 mg/kg进行雾化后有效，27%（第二组）在45分钟后以0.05 mg/kg进行第二次雾化后有效。25%的治疗（第三组）无效或仅部分有效。除两名儿童外，临床耐受性良好。第一组和第二组仅在听诊评分上存在差异。第一组和第二组的儿童比第三组的儿童年龄更大，哮喘症状也较轻。基于这项研究，雾化沙丁胺醇似乎是治疗急性哮喘的一种有效且安全的方法。在首次雾化后不久重复给予低剂量可提高反应质量。
