Langford Vets, University of Bristol Veterinary School, Bristol, BS40 5DU, UK.
J Small Anim Pract. 2021 Oct;62(10):840-849. doi: 10.1111/jsap.13326. Epub 2021 May 2.
The aim of this review was to interrogate the evidence base for treatment of keratomalacia in dogs and cats, through examination of the applicable literature.
Studies were screened for evidence to answer the following question Which of the treatment options for keratomalacia in dogs and cats offers the best chance of globe survival, the fastest time to resolution with globe survival, and the best visual outcome. The search utilised the PubMed (http://www.pubmed.gov/) and ISI Web of Science (http://wok.mimas.ac.uk/) databases. Databases were searched using the following terms: (keratomalacia OR corneal melt OR corneal malacia) AND (dog OR canine OR canid OR cat OR feline OR felid) AND (treatment OR outcome OR morbidity OR complications). Studies were assessed by one author (CH) and excluded if they related to less than three keratomalacia cases, experimental treatments, in vitro studies, or did not provide information regarding outcome. Studies were classified to a level of evidence according to the system described by the Oxford Centre for EvidenceBased Medicine.
Eighteen (18) studies were identified as providing information to answer the proposed question, one as level 3, 10 as level 4 and seven as level 5 evidence. Only one study compared two treatments, the remaining were prospective or retrospective case series of a single treatment intervention. Study design was highly variable with respect to population size, followup and outcome assessment, making direct comparison difficult, and metaanalysis was not applied.
Overall, the evidence for improved outcome of one proposed treatment over another proposed treatment for keratomalacia in dogs and/or cats is very weak.
本综述旨在通过对相关文献的研究，探讨犬猫角膜软化症的治疗方法。
筛选研究证据以回答以下问题：在治疗犬猫角膜软化症的各种方法中，哪种方法最有可能使眼球存活，使眼球存活的最快时间，以及获得最佳的视觉结果。本研究利用 PubMed（http://www.pubmed.gov/）和 ISI Web of Science（http://wok.mimas.ac.uk/）数据库进行搜索。使用以下术语搜索数据库：（角膜软化症或角膜溶解或角膜软化）和（犬或犬科或犬属或猫或猫科或猫科）和（治疗或结果或发病率或并发症）。由一位作者（CH）评估研究，并排除仅涉及少于 3 例角膜软化症的病例、实验性治疗、体外研究，或未提供有关结果信息的研究。根据牛津循证医学中心描述的系统，将研究分类为证据水平。
共确定了 18 项研究，这些研究提供了有关治疗犬猫角膜软化症的信息，其中 1 项为 3 级，10 项为 4 级，7 项为 5 级。只有一项研究比较了两种治疗方法，其余均为单一治疗干预的前瞻性或回顾性病例系列研究。研究设计在人口规模、随访和结果评估方面存在很大差异，难以进行直接比较，因此未进行荟萃分析。
总的来说，对于犬猫角膜软化症的一种治疗方法比另一种治疗方法的结果有所改善的证据非常薄弱。
