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Mineralocorticoid and Estrogen Receptors in Endothelial Cells Coordinately Regulate Microvascular Function in Obese Female Mice.肥胖雌性小鼠内皮细胞中的盐皮质激素和雌激素受体协同调节微血管功能。
Hypertension. 2021 Jun;77(6):2117-2126. doi: 10.1161/HYPERTENSIONAHA.120.16911. Epub 2021 May 3.
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Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors.心血管代谢风险因素引起的血管内皮功能障碍的性别特异性机制。
J Am Heart Assoc. 2018 Feb 16;7(4):e007675. doi: 10.1161/JAHA.117.007675.
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Essential role of bone marrow for microvascular endothelial and metabolic functions in mice.骨髓对小鼠微血管内皮和代谢功能的重要作用。
Circ Res. 2012 Jun 22;111(1):87-96. doi: 10.1161/CIRCRESAHA.112.270215. Epub 2012 May 1.
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Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway.鸢尾素通过AMPK-eNOS途径改善肥胖小鼠的内皮功能。
Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1501-8. doi: 10.1152/ajpheart.00443.2015. Epub 2015 Sep 14.
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Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.雌激素受体亚型介导雌性大鼠肠系膜微血管中不同的微血管扩张和细胞内钙离子浓度降低。
J Pharmacol Exp Ther. 2015 Feb;352(2):291-304. doi: 10.1124/jpet.114.219865. Epub 2014 Dec 3.
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Important Roles of Endothelium-Dependent Hyperpolarization in Coronary Microcirculation and Cardiac Diastolic Function in Mice.内皮依赖性超极化在小鼠冠状动脉微循环和心脏舒张功能中的重要作用。
J Cardiovasc Pharmacol. 2020 Jan;75(1):31-40. doi: 10.1097/FJC.0000000000000763.
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Calcitonin Gene-Related Peptide Protects Against Cardiovascular Dysfunction Independently of Nitric Oxide In Vivo.降钙素基因相关肽在体内独立于一氧化氮保护心血管功能障碍。
Hypertension. 2021 Apr;77(4):1178-1190. doi: 10.1161/HYPERTENSIONAHA.120.14851. Epub 2021 Mar 1.
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Eplerenone Improves Pulmonary Vascular Remodeling and Hypertension by Inhibition of the Mineralocorticoid Receptor in Endothelial Cells.依普利酮通过抑制内皮细胞中的盐皮质激素受体改善肺血管重塑和高血压。
Hypertension. 2021 Aug;78(2):456-465. doi: 10.1161/HYPERTENSIONAHA.120.16196. Epub 2021 May 10.
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GPER inhibits diabetes-mediated RhoA activation to prevent vascular endothelial dysfunction.G蛋白偶联雌激素受体（GPER）抑制糖尿病介导的RhoA激活，以预防血管内皮功能障碍。
Eur J Cell Biol. 2016 Feb;95(2):100-13. doi: 10.1016/j.ejcb.2015.12.002. Epub 2015 Dec 29.
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Fat-Specific Protein 27 Regulation of Vascular Function in Human Obesity.脂肪特异性蛋白 27 对人类肥胖症血管功能的调节作用。
J Am Heart Assoc. 2019 Jun 4;8(11):e011431. doi: 10.1161/JAHA.118.011431. Epub 2019 Jun 1.
引用本文的文献
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Improved integration of single-cell transcriptome data demonstrates common and unique signatures of heart failure in mice and humans.单细胞转录组数据的整合改进显示了小鼠和人类心力衰竭的共同和独特特征。
Gigascience. 2024 Jan 2;13. doi: 10.1093/gigascience/giae011.
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A Novel Dual-Function Nitric Oxide Donor Therapy for Preeclampsia-A Proof-of-Principle Study in a Murine Model.一种用于子痫前期的新型双功能一氧化氮供体疗法——小鼠模型的原理验证研究
Antioxidants (Basel). 2023 Nov 23;12(12):2036. doi: 10.3390/antiox12122036.
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Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice.多组学分析心脏细胞外基质，定义肥胖雌性小鼠心脏舒张功能障碍的血管贡献。
Basic Res Cardiol. 2023 Mar 29;118(1):11. doi: 10.1007/s00395-023-00983-6.
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Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia.平滑肌盐皮质激素受体促进子痫前期后的高血压。
Circ Res. 2023 Mar 17;132(6):674-689. doi: 10.1161/CIRCRESAHA.122.321228. Epub 2023 Feb 23.
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Emerging vascular cell-specific roles for mineralocorticoid receptor: implications for understanding sex differences in cardiovascular disease.醛固酮受体在血管细胞中出现的新作用：对理解心血管疾病中性别差异的意义。
Am J Physiol Cell Physiol. 2023 Jan 1;324(1):C193-C204. doi: 10.1152/ajpcell.00372.2022. Epub 2022 Nov 28.
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Mineralocorticoid Receptor Activation in Vascular Insulin Resistance and Dysfunction.矿皮质激素受体在血管胰岛素抵抗和功能障碍中的激活作用。
Int J Mol Sci. 2022 Aug 11;23(16):8954. doi: 10.3390/ijms23168954.
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The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid-induced impaired wound healing.髓系盐皮质激素受体调节糖皮质激素诱导的创伤愈合受损中的皮肤血管生成和炎症。
Br J Pharmacol. 2022 Dec;179(23):5222-5232. doi: 10.1111/bph.15932. Epub 2022 Sep 2.
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New Perspectives on Sex Steroid and Mineralocorticoid Receptor Signaling in Cardiac Ischemic Injury.心脏缺血性损伤中甾体激素和盐皮质激素受体信号传导的新视角
Front Physiol. 2022 Jun 29;13:896425. doi: 10.3389/fphys.2022.896425. eCollection 2022.
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The Regulation of Adipose Tissue Health by Estrogens.雌激素对脂肪组织健康的调节作用。
Front Endocrinol (Lausanne). 2022 May 26;13:889923. doi: 10.3389/fendo.2022.889923. eCollection 2022.
本文引用的文献
1
Dietary sodium restriction sex specifically impairs endothelial function via mineralocorticoid receptor-dependent reduction in NO bioavailability in Balb/C mice.饮食钠限制通过依赖于盐皮质激素受体的减少 Balb/C 小鼠中 NO 生物利用度而具有性别特异性地损害内皮功能。
Am J Physiol Heart Circ Physiol. 2021 Jan 1;320(1):H211-H220. doi: 10.1152/ajpheart.00413.2020. Epub 2020 Oct 23.
2
Progesterone Predisposes Females to Obesity-Associated Leptin-Mediated Endothelial Dysfunction via Upregulating Endothelial MR (Mineralocorticoid Receptor) Expression.孕激素通过上调内皮 MR（盐皮质激素受体）表达使女性易患肥胖相关瘦素介导的内皮功能障碍。
Hypertension. 2019 Sep;74(3):678-686. doi: 10.1161/HYPERTENSIONAHA.119.12802. Epub 2019 Jul 22.
3
Endothelial Mineralocorticoid Receptors Contribute to Vascular Inflammation in Atherosclerosis in a Sex-Specific Manner.内皮矿物ocorticoid 受体以性别特异性方式促进动脉粥样硬化中的血管炎症。
Arterioscler Thromb Vasc Biol. 2019 Aug;39(8):1588-1601. doi: 10.1161/ATVBAHA.119.312954. Epub 2019 Jul 11.
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Sex-specific responses to mineralocorticoid receptor antagonism in hypertensive African American males and females.高血压非裔美国男性和女性中盐皮质激素受体拮抗剂的性别特异性反应。
Biol Sex Differ. 2019 May 9;10(1):24. doi: 10.1186/s13293-019-0238-6.
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Vascular Mineralocorticoid Receptor: Evolutionary Mediator of Wound Healing Turned Harmful by Our Modern Lifestyle.血管紧张素 II 型盐皮质激素受体：从有益的伤口愈合进化中介变成了我们现代生活方式的有害因素。
Am J Hypertens. 2019 Jan 15;32(2):123-134. doi: 10.1093/ajh/hpy158.
6
Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors.心血管代谢风险因素引起的血管内皮功能障碍的性别特异性机制。
J Am Heart Assoc. 2018 Feb 16;7(4):e007675. doi: 10.1161/JAHA.117.007675.
7
Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ERα/HGF/Met Pathway.巨噬细胞盐皮质激素受体缺失通过ERα/HGF/Met途径保护肝脏脂肪变性和胰岛素抵抗。
Diabetes. 2017 Jun;66(6):1535-1547. doi: 10.2337/db16-1354. Epub 2017 Mar 21.
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The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease.内皮盐皮质激素受体：从血管健康到疾病转变的介导者。
Curr Opin Nephrol Hypertens. 2017 Mar;26(2):97-104. doi: 10.1097/MNH.0000000000000306.
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Trends in Obesity Among Adults in the United States, 2005 to 2014.2005年至2014年美国成年人肥胖趋势
JAMA. 2016 Jun 7;315(21):2284-91. doi: 10.1001/jama.2016.6458.
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Obesity, hypertension and aldosterone: is leptin the link?肥胖、高血压与醛固酮：瘦素是其中的联系纽带吗？
J Endocrinol. 2016 Jul;230(1):F7-F11. doi: 10.1530/JOE-16-0160. Epub 2016 Jun 1.
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