乳腺癌患者中人类巨细胞病毒和爱泼斯坦-巴尔病毒感染：一项针对伊朗女性的分子研究。
Human cytomegalovirus and Epstein-Barr virus infections in breast cancer: A molecular study on Iranian women.
作者信息
Ghaffari Hadi, Tavakoli Ahmad, Nafissi Nahid, Farahmand Mohammad, Ghorbani Saied, Moochani Somayeh Sadat, Hashemi-Bahremani Mohammad, Alebouyeh Mahmoud Reza, Monavari Seyed Hamidreza
机构信息
Department of Bacteriology and Virology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Breast Dis. 2021;40(4):227-233. doi: 10.3233/BD-201019.
BACKGROUND AND OBJECTIVES
The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infections in breast cancer pathology is not well understood. Our study aimed to investigate the association of HCMV and EBV infections with breast cancer and distinguish the types of positive EBV and LMP-1 samples in Iranian patients.
METHODS
Seventy-two formalin-fixed paraffin-embedded (FFPE) breast cancer tissues were analyzed between December 2014 and April 2016. Samples were analyzed for HCMV and EBV using nested-PCR and conventional PCR assays, respectively. Statistical analysis was performed using SPSS software version 18.
RESULTS
Overall, HCMV and EBV genomes were detected in 6.9% and 16.7% of FFPE breast cancer tissues, respectively. Clinical factors were not statistically associated with the presence of HCMV and EBV.
CONCLUSION
In this study, we reported EBV and LMP-1 typing in breast carcinoma cases for the first time in Iran. Our findings indicate that HCMV and EBV infections are not associated with the development of breast cancer.
背景与目的
人巨细胞病毒（HCMV）和爱泼斯坦-巴尔病毒（EBV）感染在乳腺癌病理学中的作用尚未完全明确。我们的研究旨在调查HCMV和EBV感染与乳腺癌的关联，并区分伊朗患者中EBV阳性和LMP-1阳性样本的类型。
方法
2014年12月至2016年4月期间，对72份福尔马林固定石蜡包埋（FFPE）乳腺癌组织进行了分析。分别采用巢式PCR和常规PCR检测样本中的HCMV和EBV。使用SPSS 18.0软件进行统计分析。
结果
总体而言，FFPE乳腺癌组织中HCMV和EBV基因组的检测率分别为6.9%和16.7%。临床因素与HCMV和EBV的存在无统计学关联。
结论
在本研究中，我们首次在伊朗报道了乳腺癌病例中的EBV和LMP-1分型。我们的研究结果表明，HCMV和EBV感染与乳腺癌的发生无关。
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