人类在鼻咽癌病因学中的作用。
Role of human in the etiology of nasopharyngeal carcinoma.
作者信息
Ahmed Hussain Gadelkarim, Suliman Rania Saad A, Ashankyty Ibraheem M, Albieh Zaid Ali, Warille Aymen A
机构信息
Molecular Diagnostics and Personalized Therapeutics Unit, University of Hail; Department of Pathology, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia; Department of Histopathology and Cytology, FMLS, University of Khartoum, Khartoum, Sudan.
Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Sudan University for Science and Technology, Khartoum, Sudan.
出版信息
J Cancer Res Ther. 2018 Apr-Jun;14(3):583-586. doi: 10.4103/0973-1482.176175.
OBJECTIVE
The purpose of this study was to identify human Cytomegalovirus (HCMV) in tissue blocks obtained from patients with nasopharyngeal carcinoma (NPC).
MATERIALS AND METHODS
Formalin-fixed paraffin wax processed NPC tissue were obtained from 150 tissue blocks and retrospectively investigated for the presence of HCMV using polymerase chain reaction.
RESULTS
Of the 150 NPC tissue specimens, HCMV was identified in 53/150 (35.3%) of the samples. Out of the 53 samples infected with HCMV, 33/97 (34%) were among males and 20/53 (37.7%) were among females. Of the 53 positive samples, 36/53 (68%) were found to harbor Epstein-Barr virus (EBV).
CONCLUSION
The present study has shown a relatively considerable association between HCMV and NPC. The great majority of samples sheltering HCMV were also found to hide EBV, which proposes the potentiality of EBV over HCMV.
目的
本研究旨在从鼻咽癌（NPC）患者的组织块中鉴定人巨细胞病毒（HCMV）。
材料与方法
从150个组织块中获取经福尔马林固定石蜡包埋处理的NPC组织，并采用聚合酶链反应对HCMV的存在情况进行回顾性研究。
结果
在150份NPC组织标本中，53/150（35.3%）的样本检测到HCMV。在53份感染HCMV的样本中，男性为33/97（34%），女性为20/53（37.7%）。在53份阳性样本中，36/53（68%）同时检测到EB病毒（EBV）。
结论
本研究表明HCMV与NPC之间存在较为显著的关联。大多数检测到HCMV的样本同时也检测到EBV，这提示EBV相对于HCMV具有潜在优势。
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