6-乙酰吗啡：一种存在于哺乳动物大脑中的天然产物。
6-Acetylmorphine: a natural product present in mammalian brain.
作者信息
Weitz C J, Lowney L I, Faull K F, Feistner G, Goldstein A
机构信息
Addiction Research Foundation, Palo Alto, CA 94304.
出版信息
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5335-8. doi: 10.1073/pnas.85.14.5335.
Recently, we described three substances in bovine hypothalamus, adrenal, and rat brain recognized by antisera raised against morphine, and we identified one as morphine and another as codeine by GC/MS. We now report the identification of the third immunoreactive (ir) morphinan from bovine brain as 6-acetylmorphine by chemical conversion to morphine, GC/MS, and high-resolution mass measurement. 6-Acetylmorphine has not previously been described as a natural product in plants or animals, but it has long been known as the metabolite in part responsible for the biological properties of heroin. However, we have excluded slaughter-house or laboratory contamination by any morphinan as well as derivation from the morphine in tissues during our procedures. 6-Acetylmorphine is known to be more potent than morphine in vivo chiefly by virtue of its greater penetration into the central nervous system. Should morphinans prove to have physiological functions in animals, the properties of 6-acetylmorphine make it ideal for fulfilling the role of a peripheral-to-central hormone.
最近，我们描述了牛下丘脑、肾上腺和大鼠脑中三种可被抗吗啡抗血清识别的物质，并且通过气相色谱/质谱联用仪（GC/MS）鉴定出其中一种为吗啡，另一种为可待因。我们现在报告，通过化学转化为吗啡、GC/MS以及高分辨率质谱测量，从牛脑中鉴定出第三种免疫反应性（ir）吗啡喃为6-乙酰吗啡。6-乙酰吗啡此前尚未被描述为动植物中的天然产物，但长期以来它一直被认为是海洛因生物特性部分成因的代谢产物。然而，在我们的实验过程中，我们已经排除了来自屠宰场或实验室的任何吗啡喃污染以及组织中吗啡的衍生。已知6-乙酰吗啡在体内比吗啡更具效力，主要是因为它能更好地穿透中枢神经系统。如果吗啡喃在动物体内被证明具有生理功能，那么6-乙酰吗啡的特性使其成为充当外周至中枢激素角色的理想物质。
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