Bedada Fikru B, Ntekim Oyonumo E, Nwulia Evaristus O, Fungwe Thomas V, Nadarajah Sheeba Raaj, Obisesan Thomas O
Department of Clinical Laboratory Sciences, College of Nursing and Allied Health Sciences, Howard University, Washington, DC, United States.
Department of Nutritional Sciences, College of Nursing and Allied Health Sciences, Howard University, Washington, DC, United States.
Front Aging Neurosci. 2021 Apr 14;13:641758. doi: 10.3389/fnagi.2021.641758. eCollection 2021.
The ubiquitin proteasome system (UPS) and transcription factors play a pivotal role in cellular clearance and minimizing the accumulation of Aβ in neurodegeneration (ND). In African Americans (AAs) with mild cognitive impairment (MCI), the role of components of UPS and ; and whether they are amenable to exercise effects is unknown. We hypothesized that exercise can enhance cellular clearance systems during aging and ND by increasing expressions of and . To test this hypothesis, we used TaqMan gene expression analysis in peripheral blood (PB) to investigate the component of UPS and ; and provide mechanistic insight at baseline, during exercise, and in both genders. At baseline, levels of were higher in women than in men. In our attempt to discern gender-specific exercise-related changes, we observed that levels of increased in men but not in women. Similarly, levels of increased in men only. These data suggest that a graded dose of and may be beneficial when PB cells carrying and summon into the brain in response to Alzheimer's disease (AD) perturbation (docking station PB cells). Our observation is consistent with emerging studies that exercise allows the trafficking of blood factors. Given the significance of and to ND and associated muscle integrity, our findings may explain, at least in part, the benefits of exercise on memory, associated gait, and balance perturbation acknowledged to herald the emergence of MCI.
泛素蛋白酶体系统（UPS）和转录因子在细胞清除以及将神经退行性变（ND）中β淀粉样蛋白（Aβ）的积累降至最低方面发挥着关键作用。在患有轻度认知障碍（MCI）的非裔美国人（AA）中，UPS各成分的作用以及它们是否受运动影响尚不清楚。我们假设运动可以通过增加[具体成分]的表达来增强衰老和ND过程中的细胞清除系统。为了验证这一假设，我们使用TaqMan基因表达分析对外周血（PB）进行研究，以调查UPS的成分，并在基线、运动期间以及男女两性中提供机制性见解。在基线时，女性体内[具体成分]的水平高于男性。在我们试图辨别与运动相关的性别特异性变化时，我们观察到男性体内[具体成分]的水平升高，而女性没有。同样，只有男性体内[具体成分]的水平升高。这些数据表明，当携带[具体成分]的PB细胞因阿尔茨海默病（AD）扰动（对接站PB细胞）而进入大脑时，一定剂量的[具体成分]可能是有益的。我们的观察结果与新兴研究一致，即运动可促进血液因子的运输。鉴于[具体成分]对ND和相关肌肉完整性的重要性，我们的发现可能至少部分解释了运动对记忆、相关步态以及被认为预示MCI出现的平衡扰动的益处。
