Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany.
Department of Nephrology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Front Endocrinol (Lausanne). 2021 Apr 14;12:666687. doi: 10.3389/fendo.2021.666687. eCollection 2021.
Vitamin D deficiency is very common in women of reproductive age. Studies in animals suggests a link between vitamin D and reproductive hormone biosynthesis. A systematic analysis of the correlation of reproductive hormones in reproductive-aged women with both total and free vitamin D was, however, not done so far. This cross-sectional study was performed in 351 healthy reproductive age Caucasian women (median age, 28.0 years; interquartile ranges, 24.7-31.0 years). We measured serum levels of both total and free 25(OH)D, endocrinological, hematological and biochemical parameters. Spearman's rank correlations were performed to assess the correlation between 25(OH)D metabolites and selected parameters. Total vitamin D and free vitamin D measurements correlated well (rho=0.912, p < 0.0001). Both total 25(OH)D and free 25(OH)D showed significant negative correlation with FAI (rho=-0.229, p<0.0001 and rho=-0.195, p<0.0001 for total and free 25(OH)D, respectively); LH (rho=-0.177, p=0.001 and rho=-0.114, p=0.04 for total and free 25(OH)D, respectively), testosterone (rho=-0.174, p=0.001 and rho=-0.190, p<0.0001 for total and free 25(OH)D, respectively) and AMH (rho=-0.130, p=0.015 and rho=-0.107, p=0.047 for total and free 25(OH)D, respectively). Our study showed comparable correlations of both total and free 25(OH)D with endocrinological parameters, i.e. inverse correlations with free androgen index, luteinizing hormone, testosterone, LH/FSH ratio, androstenedione and anti-Müllerian hormone, and also with hematological and biochemical parameters, i.e. inverse correlations with erythrocytes, hsCRP and leukocytes count, and positive correlation with transferrin saturation, mean corpuscular hemoglobin and mean corpuscular volume in healthy reproductive age women.
维生素 D 缺乏在育龄妇女中非常普遍。动物研究表明，维生素 D 与生殖激素生物合成之间存在联系。然而，目前尚未对育龄妇女生殖激素与总维生素 D 和游离维生素 D 的相关性进行系统分析。本横断面研究纳入了 351 名健康的育龄期白种女性（中位数年龄 28.0 岁；四分位间距 24.7-31.0 岁）。我们测量了血清总 25(OH)D 和游离 25(OH)D 水平以及内分泌、血液和生化参数。采用 Spearman 秩相关分析评估 25(OH)D 代谢物与选定参数之间的相关性。总维生素 D 和游离维生素 D 测量结果相关性良好（rho=0.912，p<0.0001）。总 25(OH)D 和游离 25(OH)D 与 FAIR（rho=-0.229，p<0.0001 和 rho=-0.195，p<0.0001）、LH（rho=-0.177，p=0.001 和 rho=-0.114，p=0.04）、睾酮（rho=-0.174，p=0.001 和 rho=-0.190，p<0.0001）和 AMH（rho=-0.130，p=0.015 和 rho=-0.107，p=0.047）呈显著负相关。本研究表明，总 25(OH)D 和游离 25(OH)D 与内分泌参数具有相似的相关性，即与游离雄激素指数、黄体生成素、睾酮、LH/FSH 比值、雄烯二酮和抗苗勒管激素呈负相关，与血液学和生化参数呈负相关，即与红细胞、hsCRP 和白细胞计数呈负相关，与转铁蛋白饱和度、平均红细胞血红蛋白和平均红细胞体积呈正相关。
