P63、P16和CK17在非典型鳞状化生及宫颈上皮内瘤变中的表达
Expression of P63, P16 and CK17 in Atypical Squamous Metaplasia and Cervical Intraepithelial Neoplasia.
作者信息
Iranpour Maryam, Dabiri Shahriar, Rezazade-Jabalbarezi Mitra, Bagheri Fatemeh
机构信息
Department of Pathology, Pathology and Stem Cell Research Center, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Iran J Pathol. 2021 Spring;16(2):181-189. doi: 10.30699/IJP.2021.104280.2095. Epub 2020 Dec 26.
BACKGROUND & OBJECTIVE: Cervical intraepithelial neoplasia (CIN) is a dysmaturation process in squamous cells in epithelial layer, which highly increases the risk of developing cervical cancer. The aim of this study was to compare the expression of three biomarkers, p16, p63, and CK17 in patients with CIN and in those with atypical squamous metaplasia (ASM).
METHODS
In this study, 100 patients underwent a colposcopy-guided cervix biopsy. Immunostaining for the biomarkers was undertaken on tissue samples presented with ASM (n=50) and CIN (n=50).
RESULTS
A significant increase in immunostaining for CK7, P63, and P16 in patients with CIN was found compared to ASM subjects.
CONCLUSION
Expression of CK17, P63, and P16 in CIN varied from those in ASM. Those biomarkers could be reliable factors to distinguish ASM from CIN; however, all the biomarkers could differentiate CIN from its mimics due to their high degree of sensitivity and specificity.
背景与目的
宫颈上皮内瘤变（CIN）是上皮层鳞状细胞的发育异常过程，其极大地增加了患宫颈癌的风险。本研究的目的是比较CIN患者与非典型鳞状化生（ASM）患者中三种生物标志物p16、p63和CK17的表达情况。
方法
本研究中，100例患者接受了阴道镜引导下的宫颈活检。对呈现ASM（n = 50）和CIN（n = 50）的组织样本进行生物标志物的免疫染色。
结果
与ASM受试者相比，CIN患者中CK7、P63和P16的免疫染色显著增加。
结论
CIN中CK17、P63和P16的表达与ASM中的不同。这些生物标志物可能是区分ASM和CIN的可靠因素；然而，由于其高度的敏感性和特异性，所有这些生物标志物都可以将CIN与其相似病变区分开来。
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