Felezi Soroush, Nosrati Anahita, Eslami Jouybari Mohammad, Jafarshad Javane
Department of Pathology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Iran J Pathol. 2021 Spring;16(2):237-242. doi: 10.30699/IJP.2020.120698.2411. Epub 2020 Dec 21.
Dendritic cells (DCs) are key arms of immune system, which act in antigen presenting processes, and are considered as a bridge between innate and adaptive immune responses. DCs are found in both lymphoid and non-lymphoid organs. They are called interdigitating dendritic cells (IDCs) in secondary lymphoid organs. IDCs lack lineage surface markers and are positive for S-100 and vimentin. IDC sarcoma (IDCS) is a very rare neoplasm, which mainly affects lymph nodes, though there are reports of extra-nodal involvement. IDCS is thought to have poor prognosis. Although there is no consensus on the treatment modalities, such options as radical surgery, chemotherapy, and radiotherapy are performed depending on severity and site of the lesion. In this study, we present a case of IDCS in a 53-year-old male with a history of several skin lesions and prior diagnoses of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and metatypical carcinoma (MTC).
树突状细胞（DCs）是免疫系统的关键组成部分，在抗原呈递过程中发挥作用，被视为固有免疫和适应性免疫反应之间的桥梁。DCs存在于淋巴器官和非淋巴器官中。在次级淋巴器官中，它们被称为交错突树突状细胞（IDCs）。IDCs缺乏谱系表面标志物，S-100和波形蛋白呈阳性。IDCs肉瘤（IDCS）是一种非常罕见的肿瘤，主要累及淋巴结，不过也有结外受累的报道。IDCS的预后被认为较差。尽管在治疗方式上尚未达成共识，但根据病变的严重程度和部位，可采取根治性手术、化疗和放疗等治疗方案。在本研究中，我们报告了一例53岁男性的IDCS病例，该患者有多处皮肤病变病史，之前曾被诊断为基底细胞癌（BCC）、鳞状细胞癌（SCC）和化生型癌（MTC）。
